摘要
目的研究降钙素原监测对支气管哮喘急性发作患者抗生素使用的作用。方法本研究采用随机、对照的方法,将我院收治的60例支气管哮喘急性发作的患者分为2组,在常规治疗的同时观察组患者进行PCT监测并在其指导下使用抗生素治疗,对照组患者根据抗生素指南规范应用抗生素。比较两组患者抗生素使用率、使用疗程及住院时间及有创机械通气率、病死率差异。结果观察组抗生素使用率较对照组低,抗生素使用疗程较对照组短,差异有统计学意义(P<0.05)。观察组中抗生素使用者与未使用者治疗前PCT差异有统计学意义(P<0.001),CRP差异无统计学意义(P>0.05)。两组患者住院时间及有创机械通气率差异无统计学意义(P>0.05),两组患者均未见死亡病例。结论支气管哮喘急性发作患者根据降钙素原水平升高情况指导抗生素应用,可减少使用率和使用时间,具有重要临床意义。
Objective To investigate the value of procalciton guidance for antibiotic application in patients with acute exacerbations of asthma. Methods Sixty patients with acute exacerbation of asthma which admitted to our hospital were divided into 2 teams according to the randomized, controlled method. Except the similar routine treatment, the control group received antibiotics based on the antibiotic use guide, while the observed group were treated with antibiotics according to PCT levels. Compared the antibiotic utilization rate and duration, hospitalization time, invasive mechanical ventilation rate and fatality rate between the two groups. Results Antibiotic utilization rate of the observed group was lower than the control group, and the duration of antibiotic treatment was shorter than the control group, the difference had statistical significance（P〈0.05）. PCT had statistical difference（P〈0.001） between antibiotics users and non users in the observed group before the treatment, while CRP had no statistically difference（P〉0.05）. The difference of invasive mechanical ventilation rate and hospitalization time between the two groups had no statistical significance（P〉0.05）. There was no death case in both groups.Conclusion Procalcitonin guidance for antibiotic application in patients with acute exacerbations of asthma can reduce antibiotic utilization rate and shorten the duration of antibiotic.
出处
《分子影像学杂志》
2016年第2期147-149,共3页
Journal of Molecular Imaging
关键词
支气管哮喘
急性发作
降钙素原
治疗
抗生素
细菌感染
asthma
acute exacerbation
procalcitonin
treatment
antibiotics
bacterial infection
