摘要
瘦素是由肥胖基因编码的一种蛋白质产物,属于Ⅰ型细胞因子,瘦素受体广泛分布于下丘脑、脂肪、睾丸、胎盘等组织,具有不同的生物功能.瘦素需与靶细胞膜上的瘦素受体结合,并通过多种信号转导途径才能发挥多种生物学效应.瘦素缺乏及瘦素受体的异常均可使生殖器官形态异常和导致与生殖相关的性激素分泌异常,进而引起男性不育症.目前研究发现,瘦素水平升高与精索静脉曲张、慢性前列腺炎、肥胖引起的男性不育,以及免疫相关性不育有关.
Leptin is a protein product encoded by the obese gene,belonging to the type Ⅰ cytokine.It has been confirmed that leptin receptor is distributed in the hypothalamus,fat,testis and placenta tissue widely with different biological functions.Leptin showed a variety of biological effects with the target of leptin receptors on the cell membrane through a variety of signal transduction pathways.Deficiency of leptin or abnormality of leptin receptor can cause abnormality of reproductive organs and hormone secretion related to reproduction,thus resulting in male infertility.The present study showed that the increase of leptin levels was associated with male infertility induced by varicocele,chronic prostatitis,obesity and immune response.
出处
《国际内分泌代谢杂志》
2016年第4期281-283,共3页
International Journal of Endocrinology and Metabolism
基金
吉林省教育厅课题[吉教科合字（2012）第495号]
吉林省社科联资助课题（1123-2）
吉林医药学院专项教改课题（ZX2015-YB014）
关键词
瘦素
生殖
男性不育症
Leptin
Reproduction
Male infertility
