摘要
目的：系统评价中西医结合治疗十二指肠溃疡的临床效果。方法：检索中国期刊全文数据库、万方数据库、中国科技期刊全文数据库、Pubmed、EMbase数据库从建库到2015年12月发表的关于中西医结合治疗十二指肠溃疡的文献,并采用系统评价和meta法进行分析。结果：本研究最终纳入随机对照试验15项共1 449例十二指肠患者。meta分析显示,中西医结合治疗组的总有效率[合并OR（odds ratio）=4.49,95%CI（confidence interval）：3.09-6.52,P〈0.000 01]、治愈率（合并OR=2.22,95%CI：1.72-2.86,P〈0.000 01）均优于对照组;Hp转阴率（合并RR（relative risk）=1.16,95%CI：0.94-1.42,P=0.16）等效于对照组;且溃疡复发率（合并OR=0.20,95%CI：0.10-0.39,P〈0.000 01）和不良反应发生率（合并OR=0.33,95%CI：0.17-0.62,P=0.000 6）均低于对照组。结论：中西医结合治疗十二指肠溃疡的临床效果优于单纯西医治疗,且复发率和不良反应发生率低,但这一结论尚需更多大样本、多中心、设计合理的随机双盲对照实验来进一步证明。
Objective：To comprehensively study the effect of traditional Chinese medicine combined with Western medicine in treatment of Duodenal ulcer（DU）.Methods：Relevant literature of traditional Chinese medicine combined with Western medicine in treatment of DU published up to October 2015 were collected from databases of CNKI,VIP,Wanfang,Pubmed and EMbase,and system evaluation and meta-analysis were performed.Results：A total of 15 randomized controlled trials meet the inclusion criteria were selected for the further analysis.The meta-analysis result showed that the total effective rate（combined OR=4.49,95% CI：3.09-6.52,P〈0.000 01）and cure rate（combined OR=2.22,95% CI：1.72-2.86,P〈0.000 01）by traditional Chinese medicine combined with Western medicine in treatment of DU was better than those by western medicine;and the clearance rate of Hp（combined RR=1.16,95% CI：0.94-1.42,P=0.16）was equivalent to the control group.Moreover,the reoccurrence rate（combined OR=0.20,95% CI：0.10-0.39,P〈0.000 01）and the incidence rate of untoward reaction（combined OR=0.33,95% CI：0.17-0.62,P=0.000 6）was lower than that by Western medicine treatment group.Conclusion：Traditional Chinese medicine combined with Western medicine in treatment of Duodenal ulcer has better the total effective rate,cure rate,and lower reoccurrence rate and incidence rate of untoward reaction.But,large,randomized,double-blind,well-designed controlled trials are warranted to further support this conclusion.
出处
《亚太传统医药》
2016年第13期112-116,共5页
Asia-Pacific Traditional Medicine
基金
广西科技攻关项目(桂科攻1355004-4)
广西卫生厅中医药民族医药继承创新工程研究课题(GZZJ13-10)
