摘要
目的研究糖尿病肾病（DN）、非糖尿病肾脏疾病（NDRD）以及DN合并NDRD患者的。肾脏病理改变及临床表现特征。方法人选2004年1月至2013年12月在中山大学附属第三医院肾内科确诊为2型糖尿病合并慢性肾脏病（CKD），且在本院接受了肾脏穿刺活检术的患者110例。根据肾脏病理检查结果将患者分为DN组、NDRD组及DN合并NDRD（MIX）组。回顾性分析3组患者肾脏病理及临床表现的特点。结果NDRD组患者最常见的病理类型为膜性肾病，MIX组最常见的病理类型为IgA肾病。DN组患者贫血、糖尿病视网膜病变的发生率明显高于NDRD组（均P〈0．05），肾功能减退合并肾病综合征水平蛋白尿的比例明显高于NDRD组（P〈0．05）。结论单纯依据临床表现诊断DN或NDRD可能导致误诊误治，肾脏病理检查对2型糖尿病合并CKD患者的诊断具有重要意义。
Objective To retrospectively investigate the pathological and clinical characteristics of diabetic nephropathy and non-diabetic nephropathy diagnosed with renal pathology. Methods Data of 110 patients diagnosed as type 2 diabetes mellitus combined with chronic kidney disease （CKD） and conducted renal biopsy from January 2004 to December 2013 in our hospital were retrospectively analyzed. According to pathological diagnosis, patients were categorized into three groups： DN group, NDRD group and DN with NDRD group （MIX group）. Results Membranous nephropathy was the most prevalent pathological type in NDRD group while IgA nephropathy was the major pathological type in MIX group. Compared with NDRD, DN patients had a higher anemia and diabetic retinopathy（DR） rate （all P 〈 0.05）. The prevalence of having both nephrotic range proteinuria and kidney function decrease was higher in DN than NDRD （P 〈 0.05）. Conclusions Renal pathology is important for the differential diagnosis of DN and NDRD since there is a relatively high rate of NDRD in patients with type 2 diabetes mellitus and CKD.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2016年第6期401-405,共5页
Chinese Journal of Nephrology
基金
“十二五”国家科技支撑计划（2011BAI10B05）
关键词
糖尿病肾病
病理学
临床
临床特点
非糖尿病肾脏疾病
Diabetic nephropathies
Pathology, clinical
Clinical characteristics
Non- diabetic nephropathy
