摘要
目的:探索性激素结合球蛋白(SHBG)在多囊卵巢综合征(PCOS)中的作用。方法:比较低水平SHBG组(115例PCOS患者)、正常水平SHBG组(195例PCOS患者)和对照组(95例)之间临床生化各项指标的差异。结果:(1)低水平SHBG组胰岛素抵抗(IR)、代谢综合征(MS)发生率显著高于正常水平SHBG组和对照组(P<0.05);(2)低水平SHBG组DHEAS明显高于正常水平SHBG组(P<0.05);(3)低水平SHBG组FINS、HOMA-IR、TG、TC/HDL、TG/HDL、LDL/HDL明显高于正常水平SHBG组和对照组,其HDL明显低于正常水平SHBG组(P<0.05);(4)相关性分析显示SHBG与HDL呈正相关,与FPG、FINS、HOMA-IR、TG、TC/HDL、TG/HDL、LDL/HDL呈负相关。结论 :低水平SHBG状态下,PCOS患者具有较高的DHEAS,并易发生MS、IR及血脂紊乱。
Objective To investigate the role of SHBG in PCOS. Methods Three hundred and ten PCOS patients were divided into the low-SHBG group , the normal-SHBG group , and 95 healthy women were enrolled in the healthy control group. Results （1） In the low SHBG group, the incidences of IR and MS were higher than those in the the normal SHBG group and the healthy control group （P 〈 0.05）; （2） In the low SHBG group, DHEAS was significantly higher than that in the normal SHBG group （P 〈 0.05）; （3） In the low SHBG group, FINS, HOMA-IR, TG, TC/HDL, TG/HDL, LDL/HDL were significantly higher than those in the normal SHBG group and the healthy control group , but HDL was significantly lower than that in the normal SHBG group （P 〈 0.05）; （4） SHBG was positively correlated with HDL, but was negatively correlated with FPG, FINS, HOMA-IR, TG, TC/HDL, TG/HDL, LDL/HDL. Conclusions Uner the low SHBG level, PCOS patients have high levels of DHEAS, and SHBG may be a risk factor for MS, IR and dislipidemia.
出处
《实用医学杂志》
CAS
北大核心
2016年第12期1969-1971,共3页
The Journal of Practical Medicine
基金
国家中医药管理局国家中医临床研究基地业务建设科研专项课题(编号:JDZX2012039)
国家中医药管理局全国名老中医药专家传承工作室建设项目
关键词
多囊卵巢综合征
性激素结合球蛋白
胰岛素抵抗
Polycystic ovarian syndrome
Sex hormone-binding globulin
Insulin resistance
