期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

卵泡刺激素受体基因多态性与卵巢过度刺激综合征的相关性 被引量：10

Correlation between the follicle-stimulating hormone receptor gene polymorphism and the ovarian hyperstimulation syndrome
下载PDF
导出
摘要 目的:探索卵巢过度刺激综合征(OHSS)与卵泡刺激素受体基因(FSHR)307位点和680位点的相关性。方法:对202例接受IVF-ET治疗的女性不孕症患者的血液样本进行FSHR基因307位点和680位点的分型鉴定。结果:OHSS组患者的680这个位点中基因型频率AA,AG,GG分别为51.1%,38.3%,10.6%,等位基因频率A,G分别为70.2%,29.8%,基因型及等位基因频率分布均与非OHSS组比较差异有统计学意义,在307这个位点上未有类似发现。结论:该研究结果表明FSHR基因的Asn680Ser这个位点可能与OHSS发病相关,Thr307Ala这个位点需要进一步的研究。 Objective To investigate the relationship between OHSS and FSHR gene polymorphism. Methods Two hundred and two women were enrolled in this study. The FSHR gene polymorphisms at position 307 and 680 were detected. Results The distribution of the allele frequency and genotype frequency of the position 680 in FSHR gene were significantly different between women with OHSS or not. No significant differences of the position 307 in FSHR gene were observed. Conclusion Themutation of Asn680Ser in FSHR might be closely related with OHSS.
作者 沈亚 陈丽 谭小方 张晶晶 施蔚虹
机构地区 江苏省南通市妇幼保健院生殖中心
出处 《实用医学杂志》 CAS 北大核心 2016年第12期1994-1997,共4页 The Journal of Practical Medicine
基金 南通市社会事业科技创新与示范项目(编号:HS2014011)
关键词 卵泡刺激素受体 卵巢过度刺激综合征 单核苷酸基因多态性 Follicle-stimulating hormone receptor Ovarian hyperstimulation syndrome Single nucleotide polymorphism
分类号 R714.8 [医药卫生—妇产科学]
  • 相关文献

参考文献13

  • 1CORBETI" S, SHMORGUN D, CLAMAN P, et al. The prevention of ovarian hyperstimulationsyndrome [ J ]. J Obstet Gynaecol Can, 2014, 36 ( 11 ) : 1024-1036.
  • 2SHEIKHHA MH, EIZTEKHAR M, KALANTAR SM. Investigating the association between polymorphism of follicle-stimulating hormone receptor gene and ovarian response in controlled ovarian hyperstimulation [J]. J Hum Reprod Sci, 2011, 4(2) : 86-90.
  • 3CAMILA MT, CARLA P, EMERSON BC, et al. Ala307Thr and Asn680Ser polymorphisms of FSHR gene in human reproduction outcomes [J].Cell Physiol Biochem, 2014,34:1527-1535.
  • 4沈亚,丁家怡,施蔚虹.IVF患者输卵管积水不同预处理方式对卵巢功能的影响[J].实用医学杂志,2014,30(4):601-603. 被引量：14
  • 5YAO Y, MA CH, TANG HL, et al. Influence of follicle- stimulating hormone receptor (FSHR) Ser680Asn polymorphism on ovarian function and in-vitro fertilization outcome: a recta- analysis [J]. Mol Genet Metab, 2011, 103(4) :388-393.
  • 6DE LA, MONTANELLI L, VAN D J, et al. Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology [J]. J Clin Endocrinol Metab, 2006, 91 (2) : 555-562.
  • 7KERKELA E, SKOTI?MAN H, FRIDEN B, et al. Exclusion of coding-region mutations in luteinizing hormone and follicle- stimulating hormone receptor genes as the cause of ovarian hyperstimulation syndrome [ J ]. Fertil Steril, 2007,87 (3) : 603- 606.
  • 8TANG H, YAN Y, WANG T, et al. Effect of follicle- stimulating hormone receptor Asn680Ser polymorphism on the outcomes of controlled ovarian hyperstimulation: an updated meta-analysis of 16 cohort studies [J]. Assist Reprod Genet,2015, 32(12):1-10.
  • 9颜元良,龚志成.中国女性卵泡刺激素受体基因多态性与卵巢过度刺激综合征的研究[J].中国现代医学杂志,2013,23(18):36-40. 被引量：6
  • 10HUMAIDAN P, QUARTAROLO J, PAPANIKOLAOU EG. Preventingovarian hyperstimulation syndrome: guidance for the clinician [J]. Fertil Steril, 2010, 94(2): 389-400.

二级参考文献29

  • 1Whelan J G, Vlahos N F. The ovarian hyperstimulation syndrome [ J ]. Fertility and Sterility, 2000,73 (5) : 883-896.
  • 2Golan A, Ron-el R, Herman A, et al. Ovarian hyperstimulation syndrome: an update review [J]. Obstetrical and Gynecological Survey, 1989,44 (6) : 430-440.
  • 3Ge H S, Huang X F, Zhang W, et al. Exposure to human chorionic gonadotropin during in vitro maturation does not improve the maturation rate and developmental potential of immature oocytes from patients with polycystic ovary syndrome [ J ]. Fertil Steril, 2008,89 ( 1 ) : 98-103.
  • 4Nastri C, Ferriani R, Rocha I, et al. Ovarian hyperstimulation syndrome: pathophysiology and prevention [J]. Assisted Reprodution and genetics, 2010,27(2-3) : 121-128.
  • 5Bassi1 S, Godin P A, Stallaert S. Ovarian hypersti -mulation syndrome: a review [J]. Human Reproduction, 2002,8 (6): 559-577.
  • 6Mathur R S, Akande A V, Keay S D, et al. Distinction between early and late ovarian hyperstimulation syndrome [J]. Fertil Steril, 2000,73 (5) : 901-907.
  • 7C.de Klerk E M, Heijnen E W, Macklon N S. The psychological impact of mild ovarian stimulation combined with single embryo transfer compared with conventional IVF [J]. Human Reproduction, 2006,21 (3) : 721-727.
  • 8De Sutter P. Single embryo transfer (eSET) not only leads to a reduction in twinning rates after IVF/ICSI, but also improves obstetrical and prenatal outcome of singletons [J]. Verb K Acad gcneeskd Belg, 2006,68(5-6) : 319-27.
  • 9Kjellberg A T, Carlsson P, Bergh C. Randomized single versus double embryo transfer: obstetric and paediatric outcome and a cost-effectiveness analysis [J]. Human Reproduction, 2006,21 (1) :210-216.
  • 10SIMONI M, TEMPFER CB, DESTENAVES B, et al. Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response[J]. Hum Reprod Update, 2008, 14(5): 459-484.

共引文献26

同被引文献70

引证文献10

二级引证文献69

实用医学杂志
2016年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部