摘要
目的:研究复方止血贴中各成分的止血作用。方法:通过家兔全血体外凝血考察复方止血贴中各成分对凝血时间的影响。建立大鼠股动脉创伤模型和猪股动脉穿孔出血模型,考察复方止血贴中各成分对出血时间和出血量的影响。结果:与空白对照组及盐水对照组比较,复方止血贴3个浓度组和凝血酶组的家兔全血体外凝血时间显著缩短(P<0.01);与空白对照组比较,复方止血贴3个剂量组和凝血酶贴组均能显著缩短大鼠股动脉破裂的出血时间和减少出血量(P<0.05或P<0.01);猪股动脉穿孔出血模型试验结果显示,复方止血贴组与凝血酶贴组比较止血时间显著缩短(P<0.05)。结论:复方止血贴具有明显缩短凝血时间、减少出血量的作用。
Objective：To study the hemostasis effect of the ingredients in compound hemostasis patches .Methods：The effect of the ingredients in compound hemostasis patches on the clotting time was studied by the coagulation of rabbit whole blood in vitro.The models of femoral arterial injury in rats and perforation of femoral artery in pigs were established , and the effect of the ingredients in compound hemostasis patches on the bleeding time and the bleeding loss was studied .Results：The results of the whole blood coagula-tion in vitro showed that the clotting time of the three compound hemostasis patches at different concentrations and thrombin group was significantly shorter than that of the blank control group and the saline control group （P〈0.01）.Compared with to the blank control group, the results of rat femoral artery trauma model test showed that the three patch groups and thrombin group could significantly re -duce the bleeding loss and bleeding time （P〈0.05 or P〈0.01）.The results of pig femoral artery perforation hemorrhage model test showed that the compound hemostasis patches could significantly reduce the bleeding time （P〈0.05）.Conclusion：Compound hemo-stasis patches can significantly shorten clotting time and decrease bleeding loss .
出处
《中国药师》
CAS
2016年第7期1286-1289,共4页
China Pharmacist
基金
陕西省科技统筹创新工程项目(编号:2014FWPT-01)
关键词
复方止血贴
凝血酶
氨基己酸
止血作用
Compound hemostasis patches
Thrombin
Aminocaproic acid
Hemostasis effect
