摘要
背景:血清胃蛋白酶原(PG)和胃泌素-17(G-17)水平以及幽门螺杆菌(Hp)感染与胃癌的发生关系密切。新疆维吾尔族、汉族胃癌血清PG、G-17与Hp感染关系的研究少见。目的:探讨新疆维吾尔族、汉族胃癌患者血清PG、G-17水平及其与Hp感染的关系。方法:选择198例维吾尔族胃癌和50例汉族胃癌患者,分别以同民族健康体检者作为正常对照。应用ELISA法检测血清PGⅠ、PGⅡ和G-17水平,计算PGⅠ/PGⅡ比值(PGR);应用尿素呼气试验和粪便Hp抗原行Hp检测。结果:维吾尔族、汉族胃癌组血清PGⅠ和PGR均明显低于相应对照组,血清PGⅡ和G-17明显升高(P<0.05);维吾尔族胃癌组血清PGⅠ和PGR明显低于汉族胃癌组,血清G-17明显升高(P<0.05)。维吾尔族、汉族胃癌组Hp感染率均明显高于相应对照组(P<0.05)。汉族胃癌组Hp阳性者血清PGⅠ和PGR明显低于同组Hp阴性者,血清PGⅡ、G-17明显升高(P<0.05);维吾尔族胃癌组Hp阳性者血清PGⅠ、PGⅡ、G-17明显高于Hp阴性者,PGR明显降低(P<0.05)。维吾尔族胃窦癌血清PGⅠ、PGⅡ和PGR均明显高于胃体癌和近端胃癌(P<0.05)。结论:血清PGⅠ、PGR降低和血清G-17升高可作为新疆地区维吾尔族、汉族胃癌筛查的血清学指标;维吾尔族、汉族胃癌患者血清PGⅠ、PGR和G-17水平改变与Hp感染相关。
Background： Serum levels of pepsinogen （ PG）, gastrin-17 （ G-17 ） and Helicobacter pylori （ Hp ） infection are closely associated with gastric cancer. Studies on relationship of serum levels of PG and G-17 with Hp infection in Uygur and HaM population with gastric cancer in Xinjiang area are rare. Aims： To investigate serum levels of PG and G-17 and their relationships with Hp infection in Uygur and HaM population with gastric cancer in Xinjiang area. Methods： A total of 198 Uygur and 50 HaM gastric cancer patients were enrolled, and healthy people with the same race were served as normal controls. Serum levels of PG I , PG Ⅱ , G-17 were determined by ELISA, PG I/PG Ⅱ ratio （PGR） was calculated. Urea breath test and stool Hp antigen test were used to detect Hp infection. Results： Serum PG I level and PGR in Uygur and HaM patients with gastric cancer were significantly decreased than those in corresponding control groups （ P 〈 0.05 ）, and serum levels of PG I and G-17 were significantly increased （ P 〈 0.05 ）. Serum PG I level and PGR in Uygur gastric cancer patients were significantly decreased than those in HaM gastric cancer patients （P 〈 0.05）, and serum G-17 level was significantly increased （ P 〈 0.05 ）. Hp infection rate in Uygur and HaM patients with gastric cancer were significantly increased than those in corresponding control groups （ P 〈 0.05 ）. Serum level of PG I and PGR were significantly decreased in HaM gastric cancer patients with Hp-positive than in Hp-negative patients, and serum levels of PG Ⅱ and G-17 were significantly increased （P 〈 0.05 ）. Serum levels of PG I , PG Ⅱ and G-17 were significantly increased in Uygur gastric cancer patients with Hp-positive than in Hp-negative patients, PGR was significantly decreased （ P 〈 0.05 ）. Serum levels of PG I , PG II and PGR were significantly increased in Uygnr gastric antral cancer patients than in gastric corpus cancer and proximal gastric cancer patients （ P 〈 0.05 ）. Conclusions ： Decreased serum PG I level, PGR and increased serum level of G-17 can be used as biomarkers to screen gastric cancer in Uygur and Han population in Xinjiang area. Hp infection in Uygur and Han patients with gastric cancer is related to the changes of serum level of PG I , PGR and G-17.
出处
《胃肠病学》
2016年第6期348-352,共5页
Chinese Journal of Gastroenterology
基金
新疆少数民族科技人才特殊培养计划科研项目(No.201523104)
