期刊文献+

调整D-二聚体截值在恶性肿瘤患者肺栓塞诊断中的价值 被引量:5

Diagnostic value of adjusting D-dimer cut-off point for pulmonary embolism in cancer patients
下载PDF
导出
摘要 目的评估提高D-二聚体截值在恶性肿瘤患者肺栓塞诊断中的价值。方法回顾性分析Wells评分≤4分的疑似肺栓塞患者134例,包括恶性肿瘤患者60例,非恶性肿瘤患者74例。应用ROC曲线制定疑似肺栓塞患者的诊断截值,计算不同截值的敏感度、特异度、阳性预测值及阴性预测值。结果非恶性肿瘤患者以500μg/L为截值,敏感度93.8%,特异度31.6%;恶性肿瘤患者以500μg/L为截值,敏感度100%,特异度7.9%。提高特异度至800μg/L,敏感度保持不变,特异度增加至31.6%。结论选取800μg/L为恶性肿瘤患者肺栓塞诊断截值可提高筛查效能。 Objective To assess the value of higher D-dimer cut-off point for the exclusion of pulmonary em-bolism (PE)in cancer patients.Methods Retrospective analysis were performed on 133 suspected PE patients in-cluded 60 patients with cancer and 74 patients with non-cancer.The difference of cut-off points were developed by re-ceiver operating characteristics (ROC)curves,and the sensitivity and specificity and the predictive value were com-pared and analyzed.Results The sensitivity and specificity were 93.8% and 31.6% at the cut-off point of 500μg/L in the non-cancer group.At the same cut-off point,the sensitivity and specificity were 100% and 7.9% in the cancer group.The cut-off point varying from 500μg/L to 800μg/L,the sensitivity was fixed and the specificity in-creased from 7.9% to 31.6%.Conclusion The D-dimer cut-off point (800μg/L)can increase the usefulness of the exclusion of pulmonary embolism in cancer patients.
出处 《临床肺科杂志》 2016年第8期1472-1475,共4页 Journal of Clinical Pulmonary Medicine
关键词 肺栓塞 恶性肿瘤 D-二聚体 pulmonary embolism cancer D-dimer
  • 相关文献

参考文献1

二级参考文献12

  • 1Righini M, Van Es J, Den Exter P L, et al. Age-adjusted D- dimer cutoff levels to rule out pulmonary embolism: the ADJUSTPE study [J]. JAMA, 2014, 311 (11) : 1117-1124.
  • 2Chen C, Li G, Liu YD, et al. A new D-dimer cutoff value to improve the exclusion of deep vein thrombosis in cancer patients [J]. Asian Pac J Cancer Prev, 2014, 15 (4) : 1655-1658.
  • 3Ercan S, Ozkan S, Y uce! N, et al. Establishing reference intervals for D-dimer to trimesters [J]. J Matern Fetal Neonatal Med, 2014, 8(25): 1-5.
  • 4Dubin R, Cushman M, Folsom AR, et al. Kidney function and multiple hemostatic markers: cross sectional associations in the multi-ethnic study ofatherosclerosis[J]. BMC Nephrol, 2011,12 (1) : 3.
  • 5Ma YC, Zuo L, Chen JH, et al. Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease[J]. J Am Soc Nephrol, 2006, 17( 10): 2937-2944.
  • 6Douma RA, Ie Gal G, Sohne M, et al. Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts [J]. BMJ, 2010, 340: c1475.
  • 7Konstantinides SV, Torbicki A, Agnelli G, et al. 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism [J]. Eur Heart J, 2014, 35 (43) : 3033-3069.
  • 8Karami-Djurabi R, Klok FA, Kooiman J, et al. D-dimer testing in patients with suspected pulmonary embolism and impaired renal function [J]. Am J Med, 2009, 122 (11) : 1050-1053.
  • 9Lindner G, Funk GC, Pfortmueller CA, et al. D-dimer to rule out pulmonary embolism in renal insufficiency [J]. Am J Med, 2014, 127 (4) : 343-347.
  • 10Robert-Ebadi H, Bertoletti L, Combescure C, et al. Effects of impaired renal function on levels and performance of D-dimer in patients with suspected pulmonary embolism [J] . Thromh Haemost, 2014, 112(3) : 614-620.

共引文献27

同被引文献58

引证文献5

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部