摘要
目的 探讨双歧杆菌三联活菌联合美沙拉嗪治疗溃疡性结肠炎的临床效果。方法 选取我院2014年2月-2016年2月收治的溃疡性结肠炎患者94例,随机分为两组,各47例。对照组给予美沙拉嗪治疗,观察组给予双歧杆菌三联活菌联合美沙拉嗪治疗,对比两组治疗有效率、治疗前后细胞因子水平和氧化应激水平。结果 观察组总有效率高于对照组,差异有统计学意义（P〈0.05）;观察组治疗后TNF-α、IL-6、IL-8低于对照组,IL-10高于对照组,差异有统计学意义（P〈0.05）;观察组治疗后SOD高于对照组,MDA低于对照组,差异有统计学意义（P〈0.05）。结论 双歧杆菌三联活菌联合美沙拉嗪治疗溃疡性结肠炎可明显提高疗效,改善细胞因子水平和氧化应激水平。
Objective To investigate the clinical effect of triple viable Bifidobacterium combined with the Mesalamine in the treatment of ulcerative colitis. Methods 94 patients with ulcerative colitis in our hospital from February 2014 to February 2016 were randomly divided into two groups, 47 cases in each. The control group was given the salad diazoxide treatment, the observation group was given Bifid Triple Viable combined beauty The treatment of salad. Treatment efficiency, cytokine levels and oxidative stress levels before and after treatment were compared. Results The total effective rate of observation group was higher than the control group, the difference was significant（P〈0.05）.The observation group after treatment, TNF-α,IL-6, IL-8 were lower than the control group, IL-10 was higher than the control group, significant difference（P〈0.05）. SOD in the observation group were higher than the control group, MDA was significantly lower than that of the control group（P〈0.05）. Conclusion Bifidobacterium triple viable combined Mesalamine on treating ulcerative colitis can significantly improve the curative effect, improve the level of cytokines and oxidative stress.
出处
《中国继续医学教育》
2016年第14期150-151,共2页
China Continuing Medical Education
关键词
双歧杆菌三联活菌
美沙拉嗪
溃疡性结肠炎
疗效
Bifidobacterium triple viable
Mesalamine
Ulcerative colitis
Curative effect
