摘要
术后认知功能障碍(postoperative cognitive dysfunction,POCD)是老年患者术后常见的并发症,多发生于全身麻醉后。影响POCD的相关因素有很多,其中老龄是POCD的首要危险因素。很多研究显示麻醉也是影响POCD的一个重要因素。报道称,麻醉方式对于POCD并无大的影响,而麻醉药物却能够通过很多的机制影响认知功能。其中,吸入麻醉药,尤其是异氟醚和七氟烷的作用机制得到了广泛的研究。相关研究发现,吸入麻醉药对于认知功能的作用与药物浓度有关。使用高浓度吸入麻醉药可以引起学习和记忆功能减弱;而低浓度的吸入麻醉药有缓解β样淀粉蛋白沉积,促进学习记忆的作用,但其机制需深入的研究。
Postoperative cognitive dysfunction is recognized as a common surgical procedures complication in older adults especially following the general anesthesia. The first dangerous factor influencing POCD development is aging. Many researches indicated that anesthetic might play an important role during the POCD development. It was reported that type of anesthesia did not affect learning and memory ability,but anesthetic drugs might influence the cognitive function through lots of mechanisms. Isoflurane and sevoflurane,as inhaled anesthesia drugs,have been widely researched. Related studies indicated that effect of inhaled anesthetics on cognitive function was related to the concentration of inhaled anesthesia drug. The high concentrations of inhaled anesthetics drug could decrease the learning and memory function. The low concentrations of inhalation anesthetics drug could ease the beta amylase deposition and promote the learning and memory ability. The mechanism needs further research.
出处
《神经药理学报》
2015年第3期17-21,共5页
Acta Neuropharmacologica
基金
河北北方学院自然科学研究计划项目(No.120176)
关键词
术后认知功能障碍
吸入麻醉
异氟醚
七氟烷
postoperative cognitive dysfunction
inhalation anesthesia
isoflurane
sevoflurane
