摘要
目的明确脱细胞生物羊膜应用于甲床二期愈合的甲外科手术中,是否有促进创面愈合的作用。方法将行甲床手术后创面二期愈合的患者随机分配到治疗组(n=19)和对照组(n=19),甲床手术后第1天换药时,治疗组使用羊膜后覆盖凡士林纱布;对照组仅覆盖凡士林纱布。记录换药后1h、4h、8h、12h、24h、36h、48h、72h患者疼痛评分;记录创面愈合时间、甲生长时间、患者和医生对外观的满意度。结果两组患者基线一致,从换药后4h开始至换药后48h,两组疼痛评分差异有统计学意义(P<0.05)。换药后24h治疗组全部患者疼痛消失。创面愈合时间:对照组平均需要(17.68±2.86)d,治疗组则需要(12.37±2.48)d,两者差异有统计学意义(P<0.05)。甲床手术后第1天到甲完全生长所需时间:对照组平均需要(15.63±2.00)周,治疗组则需要(13.95±1.72)周,两者差异有统计学意义(P=0.016)。甲完全生长后,甲单位外观满意度评分:对照组(7.58±1.18)分,治疗组(7.61±1.38)分,两组间差异无统计学意义(P=0.919)。结论脱细胞生物羊膜可以促进甲床手术创面愈合。
Objective To determine the effects of human acellular amniotic membrane（HAAM）on postsurgical recovery of nail beds.Methods Patients undergoing nail surgery were randomly divided into two groups：19in the experimental and 19 in the control groups.Patients in the experimental group were given HAAM before the wounds were covered with vaseline gauze the next day after surgery;whereas those in the control group received vaseline gauze dressing only.Ratings of pain were recorded when 1,4,8,12,24,36,48 and 72hafter the dressing was changed.The time when the wounds healed and the nail grew thoroughly were observed.ResultsThe characteristics of patients in the two groups were similar.The patients in the experimental group reported significantly less pain at 4hand 48 hthan those in the control group（P〈0.05）.After dress changing 24 h,pain disappear in the experimental group.The wounds of the patients in the experimental group also healed quicker〔（12.37±2.48）d〕than those in the control group〔（17.68±2.86）d,P〈0.05〕.It took（13.95±1.72）weeks for the patients in the experimental group to have their nails grown completely,compared with（15.63±2.00）weeks for those in the control group（P=0.016）.The experimental group had a similar degree of satisfaction（7.61±1.38）towards the cosmetic appearance of their nails compare the control group（7.58±1.18,P=0.919）.Conclusion HAAM can promote healing of surgical wounds on nail beds.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2016年第4期533-536,共4页
Journal of Sichuan University(Medical Sciences)
基金
国家自然科学基金(No.81502747)资助
关键词
甲外科
羊膜
二期愈合
Nail surgery
Amniotic membrane
Secondary healing
