摘要
目的探讨酒依赖患者氧化应激损伤与认知功能的关系。方法以50例符合美国精神障碍诊断与统计手册第4版酒依赖诊断标准的住院或门诊男性患者50例和40名健康体检对照组为研究对象。2组均测评认知功能量表RBANS,检测血浆中主要的自由基代谢指标:超氧化物歧化酶(SOD)活性、谷胱甘肽过氧化酶(GSH-Px)和过氧化物丙二醛(MDA)的含量。结果 2组的年龄、文化程度比较差异无统计学意义。酒依赖者存在抗氧化酶SOD、GSH-Px的减少和氧化应激指标MDA的增高,存在RBANS总分及各因子分的降低(P<0.05),其中RBANS总分及各因子分与SOD关系不明显,而RBANS总分(2.22±0.03,P<0.05)、即刻记忆(2.23±0.03,P<0.05)、注意因子(2.07±0.04,P<0.05)量表分与GSH-Px相关,RBANS总分(2.13±0.04,P<0.05)、即刻记忆(2.18±0.04,P<0.05)、视觉广度(2.12±0.04,P<0.05)、注意因子(2.46±0.02,P<0.05)、延迟记忆(2.43±0.02,P<0.01)量表分与MDA相关。结论酒依赖组存在氧化应激损伤和认知功能异常,认知功能异常与氧化应激有关。
Objective To investigate the relationship between alcohol-induced oxidative stress and cognitive impairment. Methods Fifty alcohol dependent male patients met DSM-IV Criteria and 40 healthy subjects were enrolled into this study. The repeatable battery for the assessment of neuropsychological status （RBANS） were used to assess the cognitive function, and the levels of the main mark of plasma free radical metabolism such as the activity of superoxide dismutase （ SOD）, glutathione peroxidase （GSH-Px） and malondialdehyde （MDA） were tested. Results There was no significant difference in the age and educational level between the two groups. In the observation group, the levels of SOD and GSH- Px decreased, while the level of MDA increased, and the score for total RBANS and every item decreased（ P 〈 0.05 ）. The total RBANS score did not show obvious association to the level of SOD. However, the total RBANS score（ 2.22 ± 0. 03, P 〈 0.05 ）, immediate memory factor（ 2.23 ± 0.03, P 〈 0.05 ） and attention factor（ 2.07 ± 0.04, P 〈 0.05 ） showed rela- tions to the levels of GSH-Px, and total RBANS score（2.13 ± O. 04, P 〈 0. 05 ）, immediate memory factor（2.18 ± 0.04, P 〈 0.05 ）, breadth of vision actor （ 2.12 ±0. 04, P 〈 O. 05 ）, attention factor （2.46 ± 0. 02, P 〈 0.05 ） and delayed memo- ry factor（2.43 ±0. 02 ,P 〈 0.01 ） showed correlation to the level of MDA. Conclusion The alcohol dependent patients are with oxidative stress and cognitive impairment. The abnormal cognitive function mat be related to the oxidative stress.
出处
《中华全科医学》
2016年第9期1498-1500,共3页
Chinese Journal of General Practice
基金
浙江省温州市科技局项目(Y20140421)
关键词
酒依赖
氧化应激
认知损害
Alcohol dependence
Oxidative stress
Cognitive impairment
