摘要
目的研究人生存素（Survivin）及半胱氨酸天冬氨酸蛋白酶3（Caspase-3）在眼附属器黏膜相关淋巴组织（MALT）淋巴瘤组织的表达及其相关性,探讨两者与眼附属器MALT淋巴瘤发病的关系及临床意义。方法收集经病理检查确诊的眼附属器MALT淋巴瘤组织标本50例作为实验组,同时收集反应性淋巴组织增生组织标本12例作为对照组,采用免疫组织化学染色法分别检测两组标本中Survivin及Caspase-3的表达,并对两者的相关性进行统计学分析。结果两组Survivin及Caspase-3蛋白阳性表达率比较,差异有显著意义（χ2=24.60、8.37,P〈0.05）。Survivin及Caspase-3蛋白表达均与Ann Arbor临床分期明显相关（χ~2=5.82、7.03,P〈0.05）;而与病人的年龄、性别无关（P〉0.05）。Survivin与Caspase-3在眼附属器MALT淋巴瘤中的表达呈负相关（r=-0.303,P〈0.05）。结论 Survivin及Caspase-3可能在眼附属器MALT淋巴瘤的发生发展中起一定的作用,Survivin可能通过抑制Caspase-3的活性从而抑制眼附属器MALT淋巴瘤细胞的凋亡。
Objective To investigate the expressions of Survivin and Caspase-3 in mucosa-associated lymphoid tissue（ MALT）lymphoma and their correlation,and explore the relationship between the two expressions and MALT lymphoma of ocular adnexa. Methods Fifty samples of MALT lymphoma of ocular adnexa confirmed by pathology were collected and served as experimental group,and samples of 12 cases of reactive lymphadenosis were served as control group. The expresions of Survivin and Caspase-3 in both groups were detected using immunohistochemical staining. A statistical analysis was done for both of the expressions and correlation between the two. Results The difference in positive expression rates of Survivin protein and Caspase 3 between the two groups was significant（ χ~2= 24. 60,8. 37; P 〈0. 05）. The expressions of Survivin and Caspase 3 protein were ob-viously correlated with Ann Arbor clinical staging（ χ2= 5. 82,7. 03; P 〈0. 05）,and not assoicated with patient age and gender（ P 〉 0. 05）. The expression of Survivin in MALT lymphoma was negatively correlated with Caspase 3 expression（ r =- 0. 303,P 〈 0. 05）. Conclusion Survivin and Caspase-3 probably play a certain effect on the occurrence and development of mucosa-associated lymphoid tissue lymphoma of ocular adnexa. Survivin is likely to inhibit the activity of Caspase3 thereby to refrain the apoptosis of the tumor.
出处
《齐鲁医学杂志》
2016年第3期276-279,共4页
Medical Journal of Qilu
基金
青岛市公共领域科技支撑计划项目(2012-1-3-2-14-nsh)
