中药熏蒸对膝骨性关节炎患者关节液SDF-1影响的临床研究被引量：8

Clinical Study on the Effect of Fumigation with Traditional Chinese Medicine on SDF-1in Patient with Knee Osteoarthritis

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摘要目的:观察中药熏蒸对膝骨性关节炎(KOA)患者关节液SDF-1含量的影响,探讨中药熏蒸治疗膝骨性关节炎的可能机理。方法:选取符合纳入标准的KOA患者60例,随机分为对照组和观察组,每组30例,对照组口服硫酸氨基葡萄糖片,观察组口服硫酸氨基葡萄糖片的同时配合中药熏蒸治疗,观察两组治疗前后WOMAC评分及临床疗效,比较关节液内SDF-1含量变化。结果:两组治疗临床效果均明显,治疗后WOMAC评分均明显下降,关节液内SDF-1含量均减少,但观察组临床效果更好,WOMAC评分下降更明显,关节液内SDF-1含量更多减少。结论:中药熏蒸治疗膝骨性关节炎有明显效果,可显著减少膝骨性关节炎患者关节液内SDF-1含量。 Objective：To observe the effect of fumigation with traditional medicine on the content of SDF-1 in joint fluid of knee osteoarthritis and explore the mechanism of fumigation in the treatment of knee osteoarthritis. Methods： KOA patients met the inclusion criteria were randomly divided into the control group and the treatment group, 30 cases in each group. The control group was given oral administration of Glucosamine Sulfate Tablets, and the treatment group was giv en Giucosamine Sulfate Tablets combined with Chinese herbal fumigation treatment. WOMAC score and clinical efficacy were observed before and after treatment in two groups, and the changes of SDF-1 content in joint fluid were compared. Results： After treatment, the WOMAC scores of the two groups were significantly decreased, and the content of SDF1 in the joint fluid was decreased. But the clinical effect of the treatment group was better, the WOMAC score decreased more significantly, and the content of SDF-1 in joint fluid decreased more. Conclusion： Fumigation with traditional Chinese medicine treating KOA has obvious effect, can significantly reduce the content of SDF-1 in joint fluid of patient with KOA.

作者杜传宝黄丹

机构地区广东深圳市龙岗区中医院广东深圳市罗湖区深圳平乐骨伤科医院

出处《中国中医骨伤科杂志》 CAS 2016年第7期30-32,共3页 Chinese Journal of Traditional Medical Traumatology & Orthopedics

关键词膝骨性关节炎中药熏蒸基质细胞衍生因子-1 knee osteoarthritis：fumigation with traditional Chinese medicine stromal cell derived factor-1

分类号 R684.3 [医药卫生—骨科学]

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1廖志刚,费兰波.中药熏蒸结合针灸治疗膝骨性关节炎的疗效观察[J].中国中医骨伤科杂志,2010,18(3):27-28. 被引量：13
2许天兵,潘红玲.温针加中药熏蒸治疗膝骨性关节炎35例[J].中国中医骨伤科杂志,2015,23(5):58-59. 被引量：7
3陈建慧.中药薰洗配合中医手法治疗膝关节骨性关节炎66例[J].中医正骨,2014,26(2):45-46. 被引量：28
4Kanbe K, Takagishi K, Chen Q, et al. Stimulation of ma- trix metalloprotease-3 release from human chondrocytes by the interaction of stromal-cell-derived factor-1 and CXC chemokine receptor 4[J]. Arthritis Rheum,2002,46 (1) :130-137.
5Xu Q,Sun XC,Shang XP,et al. Association of CXCL12 levels in synovial fluid with the radiographic severity of knee osteo- arthritis[J]. J Investig Med, 2012,60(6) . 898-901.
6Kanbe K, Takemura T, Takeuchi K, et al. Synovectomy reduces stromal-cell-derived factor-1 (SDF-1) which is in- volved in the destruction of cartilage in osteoarthritis and rheumatoid arthritis[J]. J Bone Joint Surg Br, 2004,86 (2) :296-300.
7Grassi F,Cristino S,Toneguzzi S, et al. CXCL12 chemo- kine up-regulates bone resorption and MMP-9 release by human osteoclasts:CXCL12 levels are increased in synovi- al and bone tissue of rheumatoid arthritis patients[J]. J Cell Physiol, 2004,199(2) . 244-251.
8Jo DY,Rafii S, Hamada T,et al. Chemotaxis of primitive hematopoietic cells in response to stromal-cell-derived fac- tor-l[J]. J Clin Invest,2000,105(1) :101-111.
9Kortesidis A, Zannettino A, Isenmann S, et al. Stromal-de- rived factor-1 promotes the growth, survival, and develop- ment of human bone marrow stromal stem cells [J]. Blood, 2005,105 (10) : 3793-3801.
10Carlson CS, Loeser RF, Purser CB, et al. Osteoarthritis in cynomolgus macaques Ill .effects of age,gender, and sub- chondral bone thickness on the severity of disease[J]. Bone Miner Res,1996,11(9) :1209-1217.