摘要
目的观察生长抑素联合乌司他丁治疗消化道出血的临床疗效及其对患者血清炎性因子的影响。方法选取2006年1月至2011年12月收治的消化道出血患者83例,将其随机分为观察组50例及对照组33例。对照组采取单纯生长抑素治疗方式,观察组在对照组治疗的基础上加用乌司他丁进行治疗。观察两组患者的临床疗效、住院时间以及出血停止时间等,并比较两组治疗前后的血清白细胞介素2(IL-2)、IL-6以及肿瘤坏死因子α(TNF-α)的变化。结果观察组治疗后的总有效率为94.00%(47/50)明显高于对照组63.63%(21/33),两组对比差异有统计学意义(P<0.05)。观察组出血停止时间和住院时间均低于对照组,差异有统计学意义(P<0.05)。两组患者治疗前IL-2、IL-6以及TNF-α含量无显著差异(P>0.05);治疗后两组的IL-2水平均较治疗前显著升高,但观察组升高更明显,差异有统计学意义(P<0.05);治疗后两组的IL-6和TNF-α水平均较治疗前均明显降低,但观察组改变更为明显(P<0.05)。结论使用生长抑素联合乌司他丁治疗消化道出血可以取得很好的效果,可改善消化道出血患者血清炎性因子的含量,提高机体的免疫力,加快恢复,缩短住院时间,取得比单纯生长抑素治疗更好的临床疗效。
Objective To observe the effect of somatostatin combined ulinastatin in treating gastrointestinal bleeding and analysis its effect on inflammatory factors. Methods 83 patients with digestive tract bleeding were selected in our hospital from January 2006 to December 2011,all of them were randomly divided into observation group and control group,33 cases in the control group and 50 cases in the observation group. The control group took somatostatin for treatment,and observation group took ulinastatin. The treatment efficacy,the length of hospitalization time and bleeding stop time were observed,and IL - 2,IL - 6 and tumor necrosis before and after treatment in the two groups were compared. Results The total effective rate of observation group was 94. 00%（47 / 50）,which was significantly lower than the control group 63. 63%（21 / 33）,and the difference was statistically significant（ P 〈 0. 05）. The length of hospitalization time and bleeding stop time in the observation group were sig-nificantly lower than the control group,and the difference was statistically significant（ P 〈 0. 05）. IL - 2,IL - 6 and TNF - α in two groups be-fore treatment showed no significant difference（ P 〉 0. 05）. After treatment,IL - 2 level was significantly higher than before treatment in the two groups,but the observation group was more significantly increased,the difference was statistically significant（ P 〈 0. 05）. After treatment,IL -6 and TNF - α levels in both groups were significantly lower than before treatment,but more significant changes in the observation group（ P 〈 0. 05）. Conclusion The combined use of somatostatin and ulinastatin treatment in gastrointestinal bleeding can achieved very good results. It may improve serum levels of inflammatory factors of gastrointestinal bleeding patients,improve the body′s immune cases,accelerate recovery,shorter hospitalization time and get more good therapeutic effect.
出处
《临床和实验医学杂志》
2016年第11期1081-1083,共3页
Journal of Clinical and Experimental Medicine
关键词
消化道出血
生长抑素
乌司他丁
炎性因子
Gastrointestinal bleeding
Somatostatin
Ulinastatin
Inflammatory cytokines
