摘要
目的探讨维甲酸对慢性阻塞性肺疾病(COPD)患者肺功能及炎症水平的影响。方法选取96例COPD患者随机分为研究组和对照组,每组48例。对照组采用常规方法治疗,研究组在对照组基础上加用维甲酸治疗,治疗8周后比较2组患者肺活量(FVC)、第1秒用力呼吸容积(FEV1)、第1秒用力呼吸容积占肺活量百分比(FEV1/FVC%)、6min步行距离(6MWD)及白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子(TNF-α)水平。结果研究组患者治疗后FVC、FEV1、FEV1/FVC%、6MWD水平均高于对照组[(2.49±0.42)L比(2.31±0.30)L,(1.97±0.32)L比(1.51±0.22)L,(83.24±12.11)%比(75.14±10.54)%,(364.8±34.5)m比(308.7±31.0)m,P<0.05或P<0.01]。研究组患者IL-6、IL-8、TNF-α水平均低于对照组[(128.4±12.5)ng·L^(-1)比(154.8±14.8)ng·L^(-1),(21.5±6.8)μg·mL^(-1)比(33.9±5.9)μg·mL^(-1),(511.7±83.0)ng·L^(-1)比(785.4±76.8)ng·L^(-1),均P<0.01]。结论维甲酸对COPD的治疗可降低患者炎症水平,提高肺功能。
Objective To investigate the effects of retinoic acid on lung function and inflammation levels in patients with chronic obstructive pulmonary disease（COPD）.Methods A total of 96 patients with COPD were randomly assigned to receive conventional therapy alone（control group, n=48）or in combination with retinoic acid treatment（study group,n=48）.The forced vital capacity（FVC）,forced expiratory volume in one second（FEV1）,FEV1/FVC ratio,6-minute walking distance（6MWD）,and levels of interleukin-6（IL-6）,interleukin-8（IL-8）and tumor necrosis factor（TNF-α）were measured after treatment for 8 weeks.Results Compared with control group,retinoic acid treatment increased FVC[（2.49±0.42）L vs （2.31±0.30）L],FEV1[（1.97± 0.32）L vs （1.51 ±0.22）L],FEV1/FVC ratio[（83.24± 12.11）% vs （75.14± 10.54）%]and 6MWD[（364.8±34.5）m vs （308.7±31.0）m],and decreased levels of IL-6[（128.4±12.5）ng. L^-1 vs （154.8±14.8）ng.L^-1 ],IL-8[（21.5 ±6.8）μg.mL^-1 vs （33.9±5.9）μg.mL^-1 ]and TNF-α[（511.7±83.0）ng.L^-1 vs （785.4±76.8）ng.L^-1 ]（P 〈0.05 or P 〈0.01）.Conclusion Retinoic acid treatment can reduce inflammation levels and improve lung function in patients with COPD.
出处
《实用临床医学（江西）》
CAS
2016年第5期6-8,共3页
Practical Clinical Medicine
基金
汕头市科技局科技计划项目(汕府科【2013】88号)
关键词
慢性阻塞性肺疾病
维甲酸
肺功能
炎症水平
chronic obstructive pulmonary disease
retinoic acid
lung function
inflammation levels
