摘要
目的探讨幽门螺杆菌(helicobacterpylori,HP)感染伴胃黏膜癌前病变与自噬因子LC3B表达水平之间的相关性。方法收集经胃镜及黏膜下活检确诊为消化性溃疡的患者263例,采用半定量RT-PCR方法检测所有患者的自噬因子LC3B表达水平,同时行碳14呼气试验进行HP检测,分别比较患者的HP阳性检出率与自噬因子LC3B表达水平之间的相关性;以及HP感染的消化性溃疡伴胃癌前病变与自噬因子LC3B表达水平之间的相关度。结果自噬因子LC3B mRNA高表达与HP检出率呈正相关;自噬因子LC3B mRNA高表达与慢性胃炎伴不典型增生组的发病率呈正相关。结论自噬因子LC3B mRNA高表达与HP感染及消化性溃疡伴胃黏膜不典型增生具有相关性。
Objective To study the correlation between helicobacterpylori（ HP） infection with gastric precancerous lesions and expression of autophagy factor LC3 B. Methods 263 cases of peptic ulcer patients confirmed by gastroenterology endoscopy and mucosal were selected,all patients included in the study received semi-quantitative RT-PCR method to detect self LC3 B bite factor expression levels of carbon-14 breath test simultaneously perform HP detect correlations were compared in patients with HP positive rate of autophagy factor LC3 B expression level; and former HP infection with gastric peptic ulcer disease autophagy factor LC3 B correlation between the expression level. Results The correlation of autophagy factor LC3 B mRNA expression with HP detection rate was positive; autophagy factor LC3 B mRNA expression in chronic gastritis with high incidence of dysplasia was positively correlated. Conclusion Autophagy factor LC3 B mRNA expression with HP infection and peptic ulcer with gastric dysplasia are relevant.
出处
《实用癌症杂志》
2016年第7期1065-1068,共4页
The Practical Journal of Cancer
