期刊文献+

脂蛋白肾小球病的诊断(附4例报告) 被引量:1

Diagnosis of Lipoprotein Glomerulopathy(A Report of Four Cases)
下载PDF
导出
摘要 目的分析、总结脂蛋白肾小球病的临床病理特点。方法回顾性分析2007年4月~2013年4月我院收治4例临床表现为蛋白尿或肾病综合征行经皮穿刺肾活检患者,肾组织除免疫荧光及光镜检查外,行冰冻切片行油红O染色及透射电子显微镜检查诊断脂蛋白肾小球病。结果 4例脂蛋白肾小球病患者血清总胆固醇及甘油三酯升高。肾组织免疫荧光检查肾小球血管襻、系膜区Ig G、Ig M微弱阳性表达;光学显微镜检可见肾小球体积增大,毛细血管襻不同程度扩张,襻内可见层状改变的大小不同、多少不等的栓子。油红O染色显示血管襻内沉积物为脂蛋白沉积或血栓;电子显微镜超微结构观察为内含颗粒状嗜锇酸脂质空泡。结论脂蛋白肾小球病属少见的肾小球病变,肾小球毛细血管襻内脂蛋白沉积或形成栓子是脂蛋白肾小球病特征性的形态学改变。 Objective To investigate the clinicopathologic features of lipoprotein glomerulopathy.Methods 4 patients with Percutaneous renal biopsy of proteinuria or nephrotic syndrome in our hospital from April 2007 to 2013 were diagnosis of lipoprotein glomerulopathy byoil red O staining and electron microscopy.Results The serum total cholesterol and triglyceride were increased in 4 patients.Renal glomerular capillary loop and mesangial showed weak positive expression of Ig G,Ig M by immunofluorescence; Glomerular volume increased and capillary loops showed varying degrees of expansion,glomerular loop observed changes of different sizes,different emboliin the lamellar.There were sediment for lipoprotein deposition or thrombusin loops by Oil red O staining,and lipid vacuoles of granular eosinophilic osmium acid byelectron microscopy.Conclusion Lipoprotein glomerulopathy is a rare disease.Clinical characteristic of lipoprotein glomerulopathy included lipoprotein deposition or the formation of embolus in glomerular capillary loop.
出处 《中国继续医学教育》 2016年第17期43-45,共3页 China Continuing Medical Education
关键词 脂蛋白肾小球病 临床病理 油红O染色 Lipoprotein glomerulopathy Clinical pathology Oil red O staining
  • 相关文献

参考文献8

二级参考文献92

共引文献36

同被引文献4

引证文献1

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部