甲硝唑与奥硝唑治疗宫颈糜烂的疗效及其对患者免疫球蛋白、炎症细胞因子的影响被引量：17

Comparison of curative effects of metronidazole and ornidazole in patients with cervical erosion and their effects on immune globulin and inflammatory cytokines

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摘要目的探讨甲硝唑与奥硝唑治疗宫颈糜烂的疗效,并分析其对患者免疫球蛋白、炎症细胞因子的影响,为其临床研究提供参考依据。方法选择2012年1月-2015年8月100例宫颈糜烂患者作为研究对象,采用随机数字表法分为观察组与对照组各50例,在微波治疗的基础上分别给予奥硝唑与甲硝唑治疗,所有患者均治疗3月,比较两组疗效,并检测治疗前后免疫球蛋白、炎症细胞因子的变化。结果观察组总有效率96.0%明显高于对照组88.0%,差异有统计学意义(P<0.05)。治疗前后两组免疫球蛋白(Ig)G、IgA、IgM比较差异均无统计学意义;治疗后观察组白细胞介素(IL)-2、IL-8、IL-13明显低于治疗前,差异有统计学意义(P<0.05);治疗后对照组IL-2、IL-8、IL-13明显低于治疗前,差异有统计学意义(P<0.05)。且治疗后观察组IL-2、IL-8、IL-13均明显低于对照组,差异有统计学意义(P<0.05)。结论宫颈糜烂患者微波治疗后行奥硝唑治疗临床疗效更明显,且可以有效降低局部炎症细胞因子水平,改善宫颈局部微环境。 OBJECTIVE To study the effect of metronidazole and ornidazole in patients with cervical erosion and their effects on immune globulin and inflammatory cytokines,so as to provide references for clinical researches.METHODS A total of 100 patients with cervical erosion were included from Jan.2012 to Aug.2015.All patients were divided into observation group and control group according to random number table method,with 50 cases in each group.Patients in observation group were given ornidazole treatment,and patients in control group were given metronidazole treatment.Followed up 3months,immune globulin and inflammatory cytokines were compared.RESULTS The total effective rate in observation group was 96.0%,which was higher than 88.0% in control group.The difference was significant（P〈0.05）.There were no differences of IgG,IgA and IgM in two groups before and after treatment（P〈0.05）.The IL-2,IL-8,IL-13 in observation group after treatment were lower than those before treatment.The differences were significant（P〈0.05）.The IL-2,IL-8,IL-13 in control group after treatment were lower than those before treatment.The differences were significant（P〉0.05）.The IL-2,IL-8,IL-13 in observation group after treatment were lower than those in control group.The differences were significant（P〈0.05）.CONCLUSION The clinical curative effect of ornidazole treatment in patients with cervical erosion is more obvious,which can effectively reduce the local inflammatory cytokine levels,and improve cervical local microenvironment.

作者李红梅靳露佳王翠玲方为公张金玲

机构地区焦作市人民医院西药剂科焦作市人民医院中药剂科河南省省直机关第一医院药剂科

出处《中华医院感染学杂志》 CAS CSCD 北大核心 2016年第14期3302-3303,3306,共3页 Chinese Journal of Nosocomiology

基金河南省卫生厅基金资助项目(201301102)

关键词甲硝唑奥硝唑宫颈糜烂免疫球蛋白炎症细胞因子 Metronidazole Ornidazole Cervical erosion Immune globulin Inflammatory cytokines

分类号 R978.1 [医药卫生—药品]

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