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阿仑膦酸钠在骨质疏松患者的脊柱骨折再发的治疗中临床疗效观察 被引量:4

Clinical evaluation of the effect of alendronate sodium in the osteoporotic patients with second fracture of vertebral fracture
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摘要 目的:研究阿仑膦酸钠对患有骨质疏松且脊柱骨折患者再发骨折的临床疗效评估。方法:收入97例长期骨质疏松且有脊柱骨折发生史的患者,随机分为接受阿仑膦酸钠治疗组49例和常规对照组48例。两组均使用基础用药碳酸钙D3片及骨化醇胶囊。分别于研究开始时和研究进行两年时对所有患者随访记录再次骨折发生率及常规双能X线骨密度检查(BMD)并结合血清骨钙素(OC)和血清I型胶原氨基末端肽(NTX)检验指标评估患者状态。结果:治疗组两年后骨折率相比对照组降低,治疗组随访两年前后比较结果,BMD均有升高而OC和NTX则下降(P<0.05)。结论:阿仑膦酸钠对于骨质疏松患者的脊柱再发骨折具有积极预防作用。 Objective:To evaluate the effect of the alendronate sodium in the osteoporotic patients with second fracture of vertebral fracture。Method:97 qualified osteoporotic patients with vertebral fracture were randomized into treatment group and control group. Both groups are treated with calcium carbonate and vitamin D3 and calcidol soft capsules,and the treatment group receive the alendronate sodium once a week. Every patient receives the examination of bone mineral density(BMD) and Serum cross-linked N-telopeptide of collagen type I(NTX)and osteocalcin before the treatment and after the treatment. Results:The second fracture rate is more higher in control group than in the treatment group,while the BMD and NTX and OC is comparably higher in the treatment group after two years with P0.05.The control group has not the same results.Conclusion:Alendronate sodium is effective to prevent the second fracture of osteoporotic patients.
作者 邱恺
出处 《北方药学》 2016年第8期14-15,共2页 Journal of North Pharmacy
关键词 阿仑膦酸钠 骨质疏松 脊柱再发骨折 Alendronate sodium Osteoporosis Spinal fractures
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