摘要
1例58岁男性患者因癫痫发作持续静脉泵入丙戊酸钠33.6 mg/ h，连续用药3 d。7 d后患者行左颞叶病灶切除术，手术次日 PLT 从入院时的242×109/ L 降至100×109/ L，未予以处理，继续按原剂量静脉泵入丙戊酸钠4 d 后 PLT 降至72×109/ L，凝血酶原时间（PT）由入院时的13.4 s 延长至20.7 s，纤维蛋白原（FIB）由2.08 g/ L 降至0.99 g/ L。考虑为丙戊酸钠所致血小板减少及低纤维蛋白原血症，遂停用丙戊酸钠并给予冷沉淀6.0 U。停用丙戊酸钠1周后复查，PLT 294×109/ L， PT 13.2 s，FIB 2.57 g/ L。
A 58-year-old male received a continuous intravenous fusion of sodium valproate 33. 6 mg/ h for 3 days because of epileptic seizure. Seven days later the patient underwent the the excision of lesion of left temporal lobe. The day after operation his platelet count（PLT）decreased from 242 × 109 / L which was tested on hospitalization to 100 × 109 / L,but he did not receive any treatment for the decreasing PLT. He received the continuous intravenous infusion of sodium valproate according to the primary dose again for 4 days. His PLT decreased to 72 ×109 / L,prothrombin time（PT）prolonged to 20. 7s from 13. 4 s, and fibrinogen（FIB）decreased from 2. 08 to 0. 99 g/ L. The patient was diagnosed as thrombocytopenia and hypofibrinogenemia induced by sodium valproate. Sodium valproate was withdrawn and cryoprecipitate 6. 0 U was given. One week after drug withdrawal the laboratory tests showed the following values：PLT 294 ×109 / L, PT 13. 2 s,and FIB 2. 57 g/ L.
出处
《药物不良反应杂志》
CSCD
2016年第3期216-217,共2页
Adverse Drug Reactions Journal
