摘要
1例11岁女性患儿因童年情绪障碍服用舍曲林25 mg、喹硫平25 mg，1次/ d。2 d 后实验室检查：WBC 4.6×109/ L，中性粒细胞计数（NEUT）1.8×109/ L。诊断：中性粒细胞减少。停用喹硫平，继续服用舍曲林，给予盐酸小檗胺84 mg、利可君20 mg，3次/ d 口服。6 d 后为改善病情，舍曲林剂量增至50 mg，1次/ d。同时加用维生素 B610 mg，3次/ d 口服。舍曲林治疗第13天，患儿 WBC 3.5×109/ L ，NEUT 1.4×109/ L，诊断为白细胞减少。舍曲林治疗第24天，患儿 WBC 3.3×109/ L， NEUT 1.4×109/ L。加用安多霖胶囊0.64 g，2次/ d 口服。次日舍曲林减量至25 mg，1次/ d，2 d 后停用。5 d 后复查，患儿 WBC 4.4×109/ L，NEUT 2.0×109/ L。给予氟伏沙明改善情绪。7 d 后，患儿WBC 4.6×109/ L，NEUT 2.3×109/ L。
An 11-year-old female patient was given sertraline 25 mg once daily and quetiapine 25 mg once daily for childhood emotional disorders. The patient＇s white blood cells count（WBC）was 4. 6 ×109 / L and neutrophil count（ NEUT）was 1. 8 ×109 / L two days later. The patient was diagnosed as neutropenia. Quetiapine was stopped and sertraline was given continually. At the same time berbamine hydrochloride 84 mg thrice daily and leucogen 20 mg thrice daily were given. Six days later,the dosage of sertraline was increased to 50 mg once daily to improve the symptoms and vitamin B6 10 mg thrice daily was given. On day 13 of sertraline therapy,the WBC was 3. 5 ×109 / L and the NEUT was 1.4×109 / L. Leukopenia was diagnosed. On day 24 of sertraline therapy,the WBC was 3. 3 ×109 / L and the NEUT was 1.4×109 / L. Anduolin（安多霖）capsules 0. 64 g twice daily were added to her regimen. Sertraline dose was reduced to 25 mg once daily the next day and was stopped 2 days later. Five days later,the patient＇s WBC was 4.4×109 / L and NEUT was 2. 0 ×109 / L. Then,fluvoxamine was given to improve mood. Seven days later,the patient＇s WBC was 4. 6 ×109 / L and NEUT was 2. 3 ×109 / L.
出处
《药物不良反应杂志》
CSCD
2016年第3期220-221,共2页
Adverse Drug Reactions Journal
基金
北京市科技计划项目( Z151100004015180)；北京市医院管理局临床医学发展专项(ZYLX201403)；北京安定医院人才培养项目(YR-G201508)Fund program Beijing Science and Technology Plan Project ( Z151100004015180)； Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201403)；Beijing Anding Hospital Cultivate Talents Project
