柴胡疏肝散合甘麦大枣汤加减治疗乳腺增生症的临床疗效研究被引量：31

A Clinical Research on the Effect of Chaihu Shugan Powder Combined with Adjusted Ganmai Dazao Decoction in Treating Mammary Hyperplasia

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摘要 [目的]观察柴胡疏肝散合甘麦大枣汤加减对肝郁气滞型乳腺增生症及情志的干预效果,探讨在疏肝理气基础上,联合宁心安神法对乳腺增生症疗效的提高作用。[方法]将入选的215例肝郁气滞型乳腺增生症患者按随机数字表法分为治疗组和对照组,治疗组106例用柴胡疏肝散合甘麦大枣汤加减治疗,对照组109例用柴胡疏肝散治疗。观察患者乳腺增生和情绪的改善状况。[结果]两组治疗后乳腺疼痛较治疗前改善,治疗组疼痛改善优于对照组,差异有统计学意义(P<0.01);两组治疗后乳腺肿块较前缩小,治疗组缩小程度多于对照组,差异有统计学意义(P<0.01)。治疗组临床总有效率为95.1%,对照组总有效率为86.8%,两组比较差异有统计学意义(P<0.01)。两组治疗后汉密尔顿焦虑量表HAMA和抑郁量表HAMD评分均显著低于治疗前,治疗组HAMA和HAMD评分均明显低于对照组,差异有统计学意义(P<0.01)。[结论]柴胡疏肝散合甘麦大枣汤加减能有效治疗肝郁气滞型乳腺增生症,明显改善患者的临床症状及情绪状态,疏肝理气合用宁心安神法可进一步调畅情志,提高乳腺增生症的治疗疗效。 [Objective] To study the clinical efficacy of using Chaihu Shugan powder combined with Ganmai Dazao decoction（with adjustments） in treating＂ Stagnation of Liver-Qi＂ type of mammary hyperplasia and its effects on emotional interventions. To study the effectiveness of using Chinese traditional medicine to improve treatment efficacy of mammary hyperplasia by relieving mental stress, tranquilizing the mind on the basis of soothing the liver and regulating Qi. [Method] 215 cases of ＂Stagnation of Liver-Qi＂ type of mammary hyperplasia are divided into two groups according to the random number table. The treatment group（N=106） is treated with Chaihu Shugan powder combined with Gaumai Dazao decoction（with adjustments）. The control group（N= 109） is treated with Chaihu Shugan powder alone. For both groups, the clinical efficacy and mood changes after treatments are compared and analyzed. [Results] Better results of breast pain relief are achieved for both groups. The improvement of pain relief is better in treatment group than in control group. The differences are statistically significant（P〈0.01）.The breast lump size is reduced in both groups, but it reduces more in treatment group with a statistical significance（P〈0.01）. The total effective rates in the treatment group and the control group are 95.1% and 86.8% respectively. The difference has statistical significance（P〈0.01）. For both groups, Hamilton Depression Rating Scale（HAMD） and Hamilton Anxiety Rating Scale（HAMA） score become much lower after treatment. HAMA score and HAMD score of treatment group are even lower than control group. The difference has statistical significance（P〈0.01）. [Conclusion] Chaihu Shugan powder combined with Ganmai Dazao decoction（with adjustments） is effective in treating ＂Stagnation of Liver-Qi＂ type of mammary gland hyperplasia. It significantly relieves clinical symptoms and improves emotional state. Emotion regulations by relieving mental stress, tranquilizing the mind on the basis of soothing the liver and regulating Qi are beneficial to increasing the efficacy of clinical treatment for mammary hyperplasia.