摘要
目的:探讨维生素E(VE)预防早产儿贫血的最佳剂量和临床疗效。方法:84例早产儿均分为大剂量VE组[20 mg/(kg·d)]、小剂量VE组[5 mg/(kg·d)]及对照组,对照组给予常规奶粉、营养支持治疗,大、小剂量VE组在对照组治疗基础上给予相应剂量VE口服,连续治疗4周,比较3组早产儿治疗前及治疗第1、第2、第3及第4周时血红蛋白浓度(Hb)、红细胞计数(RBC)、红细胞压积(Hct)、网织红细胞计数(Ret)、血清铁(SF)含量及总铁结合力(TIBC),比较治疗前后早产儿血清中的VE浓度;记录3组早产儿治疗过程中输血率及不良反应。结果:3组早产儿治疗前Hb、RBC、Hct、Ret、SF含量及TIBC比较,差异无统计学意义(P>0.05);治疗第2、第3及第4周时VE组Hb、RBC、Hct、Ret高于对照组,SF含量及TIBC低于对照组(P<0.05),治疗第1、第2、第3及第4周时大剂量VE组Hb、RBC、Hct、Ret、SF含量及TIBC与小剂量VE组比较,差异无统计学意义(P>0.05);治疗前,3组早产儿血清VE浓度比较,差异无统计学意义(P>0.05);治疗后,血清VE水平表现为大剂量组>小剂量组>对照组,差异有统计学意义(P<0.05);大、小剂量VE组早产儿输血率显著低于对照组(P<0.05)。结论:补充小剂量VE[5 mg/(kg·d)]可有效预防早产儿贫血,降低早产儿贫血发生率。
[ Abstract]Objective：To explore the best dosage and clinical effect of VE in preventing anemia in preterm infants. Methods：84 cases of preterm children were randomly divided into low-dose group （5 mg/kg·d）,high dose group（20 mg/kg·d）and control group. Control group was given con-ventional milk powder,nutrition support treatment. Based on the control group treatment,high dose group and low dose group received continuous treatment of corresponding dose of oral VE for 4 weeks. Hemoglobin concentration（ HB）,red blood cell count（ RBC）,red blood cell count（ HCT）,serum i-ron（ RET）and total iron binding capacity（ TIBC）were compared between the 3 groups before treat-ment and 1 week,2 weeks,3 weeks and 4 weeks after treatment. VE concentration in serum of pre-term infants was compared between before treatment and after treatment. Blood transfusion rate and ad-verse reactions were recorded in the 3 groups of premature infants. Results：Before treatment,there were no statistically significant differences in content of Hb,RBC,HCT,RET,SF,and TIBC be-tween the three groups（P﹥0. 05）. In VE treatment group,the content of Hb,RBC,HCT,RET and SF was significantly higher than their counterparts in control group at 2^th week after treatment,3^th week after treatment and 4th week after treatment,and the content of SF and the TIBC were significantly lower than those of control group（ P﹤0 . 05 ）. There were no statistically significant differences in con-tent of Hb,RBC,HCT,RET,SF,and TIBC between the high dose VE group and low dose VE group at 2th week after treatment,3th week after treatment and 4th week after treatment（P﹥0. 05）. Before treatment,there was no significant difference in the serum VE concentrations between the 3 groups（ P﹥0. 05）. After treatment,the level of serum VE was significantly higher than that of control group, the difference was statistically significant（ P﹤0 . 05 ）. The transfusion rate of preterm infants in VE group was significantly lower than that in control group（ P﹤0 . 05 ）. Conclusion：The supplementation of low dose VE（5 mg/kg＆#183;d）can effectively prevent premature infant anemia and reduce the inci-dence of anemia in premature infants.
出处
《贵阳医学院学报》
CAS
2016年第7期865-868,共4页
Journal of Guiyang Medical College
关键词
婴儿
早产
贫血
血液学
vitamin E
infant, premature
anemia
hematology
