摘要
目的观察α-硫辛酸在早期糖尿病肾病患者治疗中的临床疗效及对尿微量白蛋白排泄率和血浆内皮素- 1水平的影响。方法 80例早期糖尿病肾病患者随机分为对照组和试验组,各40例。对照组用常规方法治疗,试验组每天静脉滴注α-硫辛酸450 m L,2组均连续治疗2周。比较2组患者的临床疗效,观察2组患者治疗前后空腹血糖、餐后2 h血糖、收缩压、舒张压、血清超氧化物歧化酶(SOD)和丙二醛(MDA)含量。结果治疗后,试验组空腹血糖为(5.72±1.23)mmol·L^(-1),餐后2 h血糖为(9.55±1.58)mmol·L^(-1),收缩压为(117.09±5.77)mm Hg,舒张压为(84.10±5.69)mm Hg,显著低于对照组的(6.42±1.29)mmol·L^(-1),(10.59±1.66)mmol·L^(-1),(125.97±7.82)mm Hg,(90.98±5.61)mm Hg(P<0.05)。治疗后,试验组血清超氧化物歧化酶为(94.68±6.31)U·mg^(-1),显著高于对照组的(64.38±4.54)U·mg^(-1)(P<0.05);试验组丙二醛为(2.63±0.49)mmol·L^(-1),显著低于对照组的(3.98±0.16)mmol·L^(-1)(P<0.05)。治疗后,试验组尿微量白蛋白排泄率为(32.15±5.17)μg·min^(-1),血浆内皮素- 1为(20.43±2.11)ng·L^(-1),显著低于对照组的(77.95±10.79)μg·min^(-1),(59.15±6.44)ng·L^(-1)(P<0.05)。2组均无明显药物不良反应发生。结论α-硫辛酸治疗早期糖尿病肾病患者效果理想,能显著降低尿微量白蛋白排泄率和血浆内皮素-1水平。
Objective To investigate the clinical effect of α- lipoic acid in the treatment of patients with early diabetic nephropathy and its effect on urinary albumin excretion rate and plasma endothelin-1.Methods A total of 80 patients with early diabetic nephropathy were divided into control group and treatment group based on different treatment regimens,40 patients in each group. Patients in control group were given conventional treatment. Patients in treatment group were given intravenous infusion α- lipoic acid 450 m L daily. All patients were treated for 2 weeks. Clinical efficacy of two groups was compared. The fasting blood glucose,2 h postprandial blood glucose,systolic and diastolic blood pressure, serum superoxide dismutase（ SOD） and malondialdehyde（ MDA） in two groups were observed before and after treatment.Results After treatment,the fasting blood glucose,2 h postprandial blood glucose,systolic and diastolic blood pressure in treatment group were（ 5. 72 ± 1. 23） mmol · L^-1,（ 9. 55 ± 1. 58） mmol · L^-1,（ 117. 09 ± 5. 77） mm Hg,（ 84. 10 ± 5. 69） mm Hg,significantly lower than（ 6. 42 ± 1. 29） mmol · L^-1,（ 10. 59 ± 1. 66） mmol · L^-1,（ 125. 97 ± 7. 82） mm Hg,（ 90. 98 ± 5. 61） mm Hg in control group（ P〈0. 05）. After treatment,serum SOD in treatment group was（ 94. 68 ± 6. 31） U · mg^-1,significantly higher than（ 64. 38 ± 4. 54） U · mg^-1in control group（ P〈0. 05）. The MDA in treatment group was（ 2. 63 ± 0. 49） mmol·L^-1,significantly lower than（ 3. 98 ± 0. 16）mmol·L^-1in control group（ P〈0. 05）. After treatment,urinary albumin excretion rate and plasma endothelin 1 in treatment group were（ 32. 15 ± 5. 17）,（ 20. 43 ± 2. 11） ng · L^-1,significantly lower than（ 77. 95 ± 10. 79）μg·min^-1,（ 59. 15 ± 6. 44） ng·L^-1in control group（ P〈0. 05）. There was no adverse drug reactions in two groups. Conclusion The clinical efficiency of α- lipoic acid on patients with early diabetic nephropathy was significant,can significantly decreased the levels of urinary albumin excretion rate and plasma endothelin-1.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2016年第14期1276-1278,共3页
The Chinese Journal of Clinical Pharmacology
基金
山东省自然科学基金资助项目(2014ZRE27036)
