摘要
目的:观察百合甘麦汤加味治疗抑郁症的临床疗效。方法:将40患者按随机数字表法分为对照组和治疗组,每组20例。治疗组用百合甘麦汤加味治疗,方药组成:百合20 g,生地黄15 g,甘草12 g,浮小麦30 g,大枣10枚。随证加减:心烦不寐者加合欢皮、夜交藤;口干口苦者加麦冬、天花粉;郁郁寡欢者加郁金、石菖蒲;腹胀者加川厚朴、莱菔子;夹痰者加茯苓、半夏;大便秘结者加麻子仁、郁李仁;不思饮食者加神曲、山楂。水煎服,每日1剂,分早、晚两次服用。对照组口服米氮平片,每日1片。两组均治疗12周,治疗后评价临床疗效。结果:两组患者临床疗效比较,差异有统计学意义(P<0.05);汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分比较,经治疗后治疗组的评分为(18.25±0.68)分,对照组评分为(17.02±1.28)分,两组比较,差异有统计学意义(P<0.05);抑郁自评量表(self-rating depression scale,SDS)评分比较,治疗后治疗组的评分为(21.45±1.26)分,对照组的评分为(15.23±1.01)分,两组比较,差异有统计学意义(P<0.05);HAMD疗效比较,差异有统计学意义(P<0.05);本研究还对抑郁症的中医症状进行分析,认为对照组中患者健忘、失眠、治疗4周后无明显改善,其他症状如情志抑郁、委屈欲哭、胁胀满、嗳气等均与治疗前比较有明显改善。治疗8周后在健忘、失眠两个症状也较治疗前有明显改善。治疗12周后,所有症状均有改善,但治疗组优于对照组,两组比较,差异均有统计学意义(P<0.05)。结论:百合甘麦汤加味治疗抑郁症能减轻患者临床症状,疗效显著。文献引用:王永杰,魏丹丹,胡倩,等.百合甘麦汤加味治疗抑郁症临床研究[J].中医学报,2016,31(7):1050^(-1)052.
Objective： To observe the clinical efficacy of modified Baihe Gan Mai Decoction in treatment of depression. Methods： 40 cases of patients were randomly divided into control group and treatment group,with 20 cases in each group. Treatment group was treated with Baihe Gan Mai Decoction,the prescription of which is Lily 20 g,Rehmanniae 15 g,Licorice 12 g,Floating Wheat 30 g,Jujube 10 piece. Modified prescriptions were used according to the specific syndromes. The control group was treated with Mirtazapine tablets,one piece per day. Each group was treated for 12 weeks. After treatment the clinical efficacy was evaluate. Results： The difference of the clinical efficacy between the two groups was statistically significant（ P 〈0. 05）. The differences of the two groups in HAMD scores and SDS scores after treatment were statistically significant（ P 〈0. 05）. The difference of the HAMD efficacy was statistically significant（ P 〈0. 05）. The TCM symptoms of depression were compared before and after treatment. It is found that after 12 weeks of treatment,all the symptoms were improved in both groups,and the improvement of the treatment group was statistically significant than that of the control group（ P 〈0. 05）. Conclusion： modified Baihe Gan Mai Decoction in treatment of depression can achieve better clinical efficacy in treatment of depression and significantly improve the clinical symptoms.
出处
《中医学报》
CAS
2016年第7期1050-1052,共3页
Acta Chinese Medicine
基金
河南省科技攻关项目(122102310163)
河南中医学院博士启动基金项目(BSJJ2010-38)
关键词
抑郁症
百合甘麦汤
百合地黄汤
甘麦大枣汤
米氮平
depression
Baihe Gan Mai Decoction
Baihe Dihuang Decoction
Gan Mai Dazao Decoction
Mirtazapine
