摘要
目的:观察促红细胞生成素(EPO)对急性心肌梗死患者经皮冠状动脉介入治疗(PCI)术后再灌注性心律失常的影响。方法:选取急性ST段抬高型心肌梗死且成功行PCI的患者120例,将其随机分为EPO 100 U/kg组、EPO 1 000 U/kg组及对照组,每组40例。EPO 100 U/kg组和EPO 1 000 U/kg组在PCI术前分别给予100 U/kg和1 000U/kg的EPO,对照组给予0.9%氯化钠溶液,观察PCI术后再灌注性心律失常发生情况,记录随访期间的主要不良心脏事件(MACE)及EPO相关不良反应发生情况。结果:共74例出现再灌注性心律失常(63.33%)。EPO 1 000 U/kg组房性期前收缩、心房颤动、室性期前收缩、室性心动过速、总心律失常发生率及室性心律失常评分均低于对照组(均P<0.05);EPO 100U/kg组房性期前收缩、心房颤动、室性期前收缩发生率低于对照组(均P<0.05)。3组患者随访6个月后不良反应发生无统计学差异。结论:急性心肌梗死患者PCI术前给予EPO对再灌注性心律失常具有一定缓解作用。
Objective:To explore the effect of erythropoietin(EPO)on reperfusion arrhythmia in patients with acute myocardial infarction after PCI.Method:A total of 120 AMI patients after PCI was randomized into EPO100U/kg group,EPO 1 000U/kg group and control group.Patients in EPO 100U/kg group and EPO 1 000U/kg group were given 100U/kg or 1 000U/kg EPO before PCI,while saline was given in control group.The occurrence of reperfusion arrhythmia was detected.EPO related side effects and major adverse cardiovascualer events(MACE)were also compared.Result:The occurrence of reperfusion arrhythmia was 63.33%(76/120)among all patients.The incidence of atrial premature beats,auricular fibrillation,premature ventricular contraction,ventricular tachycardia,overall arrhythmia and ventricular arrhythmia score were significantly lower in EPO 1000U/kg group(all P〈0.05);the incidence of atrial premature beats,auricular fibrillation and premature ventricular contraction were lower in EPO100U/kg group than in control group(all P〈0.05).The incidence of EPO related side effects and MACE among the three groupswere not significant different.Conclusion:The administration of EPO before PCI might has positive effects on the control of reperfusion arrhythmia.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2016年第7期690-693,共4页
Journal of Clinical Cardiology
基金
河南省2014年国际科技合作计划项目(No:144300510074)
河南省基础与前沿技术研究计划项目(No:152300410065)