CD64指数、PCT和WBC在临床细菌感染疾病中的诊断价值被引量：4

下载PDF

导出

摘要目的探讨外周血白细胞分化抗原64(CD64)指数、血清降钙素原(PCT)和白细胞计数(WBC)在临床细菌感染疾病中的诊断价值。方法收集住院患者132例,包括全身感染组(67例)和局部感染组(65例),另收集健康体检63例作为对照组。分别检测外周血CD64表达、血清PCT水平和WBC,采用ROC曲线分析比较三者的诊断效能,Pearson相关性分析三者的相关性。结果与对照组相比,全身感染组和局部感染组的CD64指数、PCT水平和WBC均有显著性升高(P<0.001)。与局部感染组相比,全身感染组CD64指数和PCT水平明显升高(P<0.01),而两组间WBC差异无统计学意义(P>0.05)。ROC曲线显示,取最佳截断值时,CD64对诊断临床细菌感染敏感性和特异性分别为84.8%和95.2%,PCT为87.1%和98.4%,而WBC为74.8%和96.8%。CD64指数与PCT的曲线下面积(AUC)无明显差异,而二者的AUC均明显大于WBC的AUC(P<0.001)。Pearson相关性分析,在临床细菌感染时,CD64指数与PCT、WBC呈正相关,协同升高。结论 CD64指数和PCT在临床细菌感染疾病中均有较高的诊断价值,其诊断效能稍优于WBC。

作者郑立明

机构地区江苏省常州市第三人民医院检验科

出处《国际检验医学杂志》 CAS 2016年第14期2018-2019,共2页 International Journal of Laboratory Medicine

关键词 CD64 降钙素原白细胞细菌感染

分类号 R515 [医药卫生—内科学] R446.1 [医药卫生—诊断学]

引文网络
相关文献

参考文献11

1Levy MM,Fink MP,Marshall JC,et al.2001 sccm/esicm/ accp/ats/sis international sepsis definitions conference [J],Intensive Care Med,2003,29(4):530-538.
2Hoffmann JJ.Neutrophil CD64: a diagnostic marker for infection and sepsis [J].Clin Chem Lab Med,2009,47(8):903-916.
3李德红,居军.诊断感染性疾病的新指标:中性粒细胞CD64[J].检验医学,2012,27(1):67-70. 被引量：35
4Gerrits JH,Mclaughlin PM,Nienhuis BN,et al.Polymor- phic mononuclear neutrophils CD64 index for diagnosis of sepsis in postoperative surgical patients and critically ill patients[J].Clin Chem Lab Med,2013,51(4):897-905.
5Elawady S,Botros SK,Sorour AE,et al.Neutrophil CD64 as a diagnostic marker of sepsis in neonates[J].J Investig Med,2014,62(3):644-649.
6Ckayama Y,Krishenbaum AS,Metcalfe DD.Exprefession of a functional high-affinity IgG receptor,Fe gamma RI,on human mast cells : UP-regulation by IFN gamma[J].J Immunol,2000,164(8):4332-4339.
7冯萍,虞培娟,朱雪明.细菌感染患者外周血中性粒细胞表面CD64指数的变化[J].检验医学,2010,25(2):96-99. 被引量：30
8Mussap M,Degrandi R,Cataldi L,et al.Biochemical markers for the early assessment of neonatal sepsis: the role of procalcitonin [J].J Chemother,2007,19( Suppl 2);35-38.
9Sridharan P,Chamberlain RS.The efficacy of procalcito- nin as a biomarker in the management of sepsis : slaying dragons or tilting at windmills [J].Surg Infect (Larch- mt),2013,14(6):489-511.
10王贤,张葵,夏永泉.CD64指数对临床细菌感染患者的诊断价值[J].中华实用诊断与治疗杂志,2011,25(10):1035-1036. 被引量：12

二级参考文献38

1Davis BH. Improved diagnostic approaches to infection/ sepsis detection [ J]. Expert Rev Mol Diagn, 2005,5 (2) :193-207.
2Ng PC, Li G, Chui KM, et al. Neutrophil CD64 is a sensitive diagnostic marker for early-onset neonatal infection[ J]. Pediatr Res,2004,56(5 ) :796-803.
3Zhang G, Qiao S, Li Q, et al. Molecular cloning and expression of the porcine high-affinity immunoglobulin G Fc receptor (FcgammaRI)[J]. Immunogenetics, 2006, 58(10) :845-849.
4Danikas DD, Karakantza M, Theodorou GL,et al. Prognostic value of phagocytic activity of neutrophils and monocytes in sepsis. Correlation to CD64 and CD14 antigen expression[J]. Clin Exp Immunol, 2008, 154 ( 1 ) : 87-97.
5Allen E, Bakke AC,Purtzer MZ, et al. Neutrophil CD64 expression : distinguishing acute inflammatory autoimmune disease from systemic infections[J]. Ann Rheum Dis,2002,61 (6) : 522-525.
6Davis BH,Olsen SH, Ahmad E, et al. Neutrophil CD64 is an improved indicator of infection or sepsis in emergency department patients [J].Arch Pathol Lab Med, 2006, 130 (5) :654-661.
7Nuutila J, Hohenthal U, Laitinen I, et al. Simultaneous quantitative analysis of FcgammaRI (CD64) expression on neutrophils and monocytes: a new, improved way to detect infections [ J]. J Immunol Methods, 2007, 328 (1-2) : 189-200.
8Zarev PV, Davis BH. Comparative study of monocyte enumeration by flow cytometry: improved detection by combining monocyte-related antibodies with anti-CD163 [J].Lab Hematol, 2004, 10(1) :24-31.
9Standage S W, Wong H R. Biomarkers for pediatric sepsis and septic shock[J]. Expert Rev Anti Infect Ther,2011,9(1):71- 79.
10Cid J, Garcia Pardo G, Aguinaco R, et al. Neutrophil CD64: diagnostic accuracy and prognostic value in patients presenting to the emergency department[J]. Eur J Clin Microbiol Infect Dis, 2011,30(7) :845-52.