摘要
免疫功能低下、免疫调节功能失调/紊乱是乙型肝炎病毒感染发生、发展的主要发病机制,因此调节机体免疫功能对慢性乙型肝炎的抗病毒治疗尤为重要.近年中药单体、单味药及中药复方治疗慢性乙型肝炎已取得了较好的疗效,但其具体的机制尚不明确.本文从促进树突状细胞成熟和功能恢复、调节NK/NKT功能、调节肝脏巨噬细胞功能、通过双向调节免疫功能调节T细胞功能等四个方面阐述中医药治疗慢性乙型肝炎的作用机制.
The low immune function and immune dysregulation/disorder are important mechanisms responsible for the occurrence and development of hepatitis B virus infection.Therefore,it is important to improve the immune function while administering antiviral treatment.In recent years,traditional Chinese medicine（TCM） in the treatment of chronic hepatitis B has shown promising curative effects,but the mechanism is not dear.This article will review the immunological mechanism of TCM in the treatment of chronic hepatitis B with regard to promoting the maturation and function recovery of dendritic cells and regulating the function of natural killer cells,natural killer T cells,Kupffer cells and T cells.
出处
《世界华人消化杂志》
CAS
2016年第19期2943-2949,共7页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.81503545
上海市科委扬帆计划基金资助项目
No.15YF1412300
上海中医药大学预算内基金资助项目
No.2014YSN39~~
关键词
慢性乙型肝炎
中医药
治疗
免疫机制
Chronic hepatitis B
Traditional Chinese medicine
Treatment
Immunological mechanism
