摘要
目的:观察中医桂枝芍药知母汤加味治疗类风湿性关节炎(RA)的临床效果。方法:采用前瞻性的研究方法,将本院风湿内分泌科收治的88例RA患者进行随机分组,中西医组采用甲氨蝶呤加桂枝芍药知母汤治疗,西医组采用甲氨蝶呤加雷公藤多苷治疗,两组患者疗程均为2个月。结果:治疗前两组患者的临床症状、中医证候积分、各实验室指标差异均无统计学意义(P>0.05);治疗后,中西医组肿胀关节数、晨僵时间、双手握力显著低于西医组(P<0.05),中西医组血清IL-6、CRP、OPG、ESR、RF值显著低于西医组(P<0.05),治疗后中西医组中医证候总积分显著低于西医组(P<0.05);治疗2个月后,中西医组愈显率(63.64%)显著高于西医组(40.91%)(P<0.05)。结论:中医桂枝芍药知母汤加味结合常规疗法治疗RA患者的效果显著的优于单纯西医治疗。
Objective： Discussing the effect of using Modified Guizhi Shaoyao Zhimu Decoction in the treatment of rheumatoid arthritis（ RA）. Methods： A prospective study on 88 patients with RA admitted to hospital with rheumatoid endocrinology randomized,the treatment group（ methotrexate add Guizhi Shaoyao Zhimu Decoction） and the western medicine group（ methotrexate add tripterygium glycosides）,each group had 44 cases,two groups of patients were with a course of two months. Results： Before treatment： clinical symptoms of the two groups of patients,symptom scores,each laboratory parameters showed no significant difference（ P〉0. 05）; after treatment： number of swollen joints in patients with the treatment group,duration of morning stiffness,grip strength double significantly were lower than the western medicine group patients（ P〈0. 05）,serum IL-6,CRP,OPG,ESR,RF of the treatment group was significantly lower than the western medicine group（ P〈0. 05）,syndromes total score of patients in the treatment group after treatment was significantly lower than the western medicine group（ P〈0. 05）; 2months after treatment,markedly effective rate in the treatment group（ 63. 64%） was significantly higher than the western group（ 40. 91%）（ P〈0. 05）. Conclusion： The effect of using Guizhi Shaoyao Zhimu Decoction combined with conventional therapy in the treatment of RA is significantly better than the treatment of western medicine only.
出处
《四川中医》
2016年第7期111-113,共3页
Journal of Sichuan of Traditional Chinese Medicine
关键词
桂枝芍药知母汤
中西医
类风湿性关节炎
Guizhi Shaoyao Zhimu Decoction
Traditional Chinese and western medicine
Rheumatoid arthritis
Curative effect
