摘要
目的：探讨术前卡铂不同途径单次给药对肿瘤组织药物聚集浓度与化疗效果的影响。方法：60例可切除进展期胃癌患者随机分为腹腔给药组（30例）和静脉给药组（30例）。两组患者均给予卡铂注射液50 mg/m2,静脉滴注,连用5 d后休息4周,重复3次。最后一次给药时,腹腔给药组患者给予卡铂注射液30 mg/m2,加入0.9%氯化钠注射液750 ml中,放置在37℃水浴锅中预热,采取腹腔穿刺的方式一次性快速注射。静脉给药组患者给予卡铂注射液30 mg/m2,加入0.9%氯化钠注射液750 ml中,静脉滴注,并在30 min内滴完。两组均给药1次并于至少1周后进行手术。于两组患者给药160～180 min、250～260 min后测定患者各组织中卡铂聚集浓度,并记录最后一次给药5 d后疗效和不良反应发生情况。结果：腹腔给药组患者5 d后总有效率,给药160～180 min后腹腔液、门静脉血和外周血,给药250～260 min后癌组织、癌旁正常组织、腹膜、大网膜和阴性淋巴结中卡铂聚集浓度均显著高于静脉给药组,不良反应发生率显著低于静脉给药组,差异均有统计学意义（P〈0.05）。结论：术前单次腹腔注射较静脉滴注卡铂能提高肿瘤局部药物聚集浓度,提高化疗效果,降低不良反应发生率。
OBJECTIVE：To observe the effects of single administration of carboplatin by different ways on drug accumulation concentration and treatment of tumor tissue before surgery. METHODS：60 patients with resectable advanced gastric cancer were randomly divided into intraperitoneal administration group（30 cases）and intravenous administration group（30 cases）. All patients received 50 mg/m2 Carboplatin injection,intravenous administration,it stopped 4 weeks after continuous 5 d,repeated 3 times,when the last chemotherapy,intraperitoneal administration group was given 30 mg/m2 Carboplatin injection,adding into 750 ml0.9% Sodium chloride injection,and placed in 37 ℃ water bath for preheating,taking paracentesis for disposable rapid injection.Intravenous administration group was 30 mg/m2 Carboplatin injection,adding into 750 ml 0.9% Sodium chloride injection,by intravenous infusion within 30 min. Both groups were administered once for at least 1 week,then surgery was taken after 5 d. The carboplatin accumulation concentration in 2 groups was determined after 160-180 min and 250-260 min,respectively,and the efficacy in the 5th day and incidence of adverse reactions during treatment were recorded. RESULTS：The total effective rate after 5 d,peritoneal fluid,portal vein and peripheral blood after 160-180 min,and carboplatin accumulation concentration in cancer tissues,adjacent normal tissues,peritoneum,omentum and negative lymph node after 250-260 min in intraperitoneal administration group were significantly higher than intravenous administration group,the incidence of adverse reactions was significantly lower than intravenous administration group,the differences were statistically significant（P〈0.05）. CONCLUSIONS：Compared with intravenous infusion,intraperitoneal injection of carboplatin before surgery can improve the local accumulation concentration and chemotherapeutic effect and reduce incidence of adverse reactions.
出处
《中国药房》
CAS
北大核心
2016年第21期2913-2915,共3页
China Pharmacy
关键词
卡铂
腹腔注射
静脉滴注
肿瘤组织
药物聚集浓度
Carboplatin
Intraperitoneal injection
Intravenous infusion
Tumor tissue
Drug accumulation concentration
