摘要
目的双侧原发性乳腺癌（bilateral primary breast cancer，BPBC）虽然是一种少见类型乳腺癌，但在我国患病人数仍很可观，而且我国乳腺癌发病年龄趋于年轻化，直接影响了患者的治疗效果。本研究旨在探讨年轻双侧BPBC的临床病理特征、诊断、综合治疗及预后。方法对天津医科大学肿瘤医院2005—01—01—200812—31收治的15例≤40岁（30～40岁）BPBC患者的临床资料进行回顾性分析，并与同期118例非年轻（〉40岁）BPBC患者进行对比。结果年轻BPBC占同期全部BPBC的11．3％，年轻与非年轻BPBC的，临床特征进行比较发现，年轻BPBC患者初潮年龄旱，生育次数少，第二原发癌处于病理学分期Ⅱ期的患者比例高，以上特征差异均有统计学意义，P〈0．05。年轻BPBC与非年轻BPBC的5年无病生存率分别为71．1％和84．9％，差异无统计学意义，P=0．335；5年总生存率分别为73．3％和87．2％，差异无统计学意义，P=0．487。结论年轻BPBC作为一种特殊类型的BPBC，与非年轻BPBC的临床病理特征上存在明显差异，这导致了二者预后的不同，但这种差异无统计学意义。单侧年轻乳腺癌术后患者为发生对侧乳腺癌的高危人群，应加强随访，以期做到早发现、早诊断、早治疗，改善预后。
OBJECTIVE Bilateral primary breast cancer（BPBC） is a rare type of breast cancer, but the number of patients in China is large. The age of onset of breast cancer in China tends to be younger, which directly affect the treat- ment effect of the patients. This study aimed to explore the clinicopathological characteristics, diagnosis, muhidispline therapy and prognosis of young BPBC. METHODS Clinical data of 15 patients with young BPBC in cancer institute and hospital of Tianjin medical university from January 1st 2005 to December 31th 2008 were retrospectively analyzed and compared with 118 patients who were not young bilateral primary breast cancer. RESULTS Young BPBC accounted 11.3 % of the entire BPBC. Compared with not young BPBC, young BPBC had earlier menarche and fewer fertility. And those whose second primary cancer in the stage Ⅱ accounted for a larger proportion. All the results mentioned above had statistical significance. However, the five-year disease free survival （DFS） rate and the 5-year overall survival （OS） rate had no significant difference between young BPBC and not young BPBC （71. 1% vs 84. 9%, P=0. 335; 73. 3% vs 87.2%, P=0. 487, respectively）. CONCLUSIONS Compared with not young BPBC, young BPBC had many differences in clinicopathological characteristics. However, there was no statistical significance regarding survival. The young people who received the unilateral breast radical mastectomy had higher risk to get contra lateral breast cancer. In order to have early detection, diagnosis and treatment, we should strengthen the follow-up for high risk patients.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2016年第10期652-656,共5页
Chinese Journal of Cancer Prevention and Treatment
关键词
年轻
乳腺肿瘤
诊断
综合治疗
预后
young
breast neoplasms
diagnosis
combined therapy
prognosis
