摘要
目的:探讨乌腺金丝桃对类风湿关节炎大鼠的治疗作用。方法:以胶原诱导性(CIA)大鼠为实验模型,以雷公藤多苷为阳性对照药,观察乌腺金丝桃对类风湿关节炎大鼠血清中NO含量及滑膜组织中VEGF含量的影响。结果:与模型组比较,乌腺金丝桃和雷公藤多苷均能抑制类风湿关节炎大鼠NO及VEGF的表达(P<0.01或P<0.05)。结论:乌腺金丝桃可能通过降低类风湿关节炎大鼠过高的NO及VEGF含量发挥治疗作用。
Objective ： To investigate the effect of Hypericum attenuatum Choisy on the rats with rheumatoid ar- thritis. Methods： Collagen -induced rats were as the experimental models, and the content of VEGF in serum of patients with rheumatoid arthritis was observed by using tripterygium glycosides as the control medicine. Re- suits： Compared with the model group, Hyperieum attenuatum Choisy and tripterygium glycosides could inhibit the expression of NO and VEGF in rheumatoid arthritis rats （P 〈 0.01 or P 〈 0.05 ）. Conclusion： Hypericum attenuatum Choisy can play an effective role in anti -inflammation and regulating immune by reducing the ex- cessive contents of NO and VEGF in the rats with rheumatoid arthritis.
出处
《中医药信息》
2016年第4期4-6,共3页
Information on Traditional Chinese Medicine
