摘要
目的观察胸腺法新注射液联合化疗对老年胃癌伴肝转移患者的疗效。方法选择2013年10月-2015年10月于西安市第一医院老年消化内科治疗的晚期胃癌伴肝转移患者76例为研究对象,按照随机双盲法分成对照组和观察组,每组38例,对照组予以顺铂联合替吉奥胶囊、5-氟尿嘧啶治疗,观察组在此基础上加用胸腺法新治疗,观察2组患者的临床疗效、生活质量、肝功能变化,并观察患者的药物不良反应。结果观察组近期总有效率为63.2%(24/38),显著高于对照组的36.8%(14/38),差异有统计学意义(χ~2=8.81,P=0.045);生活质量总改善率观察组患者为81.5%(31/38),显著高于对照组的65.7%(25/38),差异有统计学意义(χ~2=7.22,P=0.034)。治疗前2组ALT、胆红素、白蛋白、球蛋白比较无显著性差异(P>0.05),治疗后2组上述指标均改善(观察组:t=2.378、2.165、2.367、2.045,对照组:t=2.175、2.147、2.059、2.372,P<0.05),且观察组改善幅度优于对照组(t=2.608、2.514、2.414、2.389,P<0.05)。治疗前2组的胃癌标志物AFP、CEA、CA199水平比较,差异无统计学意义(P>0.05),治疗后2组上述指标均改善(观察组:t=2.174、2.279、2.141,对照组:t=2.154、2.049、2.387,P<0.05),且观察组改善幅度优于对照组(t=2.412、2.389、2.369,P<0.05)。患者用药后主要的不良反应包括三系细胞减少、腹泻、口腔黏膜炎以及神经毒性等,但2组患者不良反应发生率比较差异无统计学意义(χ~2=0.740、0.390、0.510、0.420,P>0.05)。结论胸腺法新注射液联合化疗对于老年胃癌伴肝转移患者疗效较为显著,在提高患者生活质量、改善肝功能的同时不增加药物不良反应,值得临床推广应用。
Objective To observe the effect of thymus injection combined with chemotherapy in the treatment of elderly patients with gastric cancer with b＇ver metastasis.Methods Selection of 76 cases of advanced gastric cancer patients with liver metastasis in the first hospital of Xian city from October 2013 to October 2015,according to the randomized double blind method,they were divided into two groups,the control group and the observation group,38 cases in each group.The control group was given cisplatin combined with S-1 capsule,5 fluorouracil,on this basis of treatment in the control group,the observation group was treated with thymus method,the clinical effect,quality of life and liver function of the 2 groups were observed,and the adverse drug reactions were observed.Results The observation group recent total efficiency was 63.2%（24/38）,which was significantly higher than that of control group of 36.8%（14/38）,the difference is statistically significant（χ~2=8.81,P =0.045）.Quality of life total improvement rate of the observation group was 81.5%（31/38）,which was significantly higher than that in control group＇s 65.7%（25/38）,the difference was statistically significant（chi square =7.22,P =0.034）.Before treatment,2 groups＇ ALT,bilirubin,albumin,globulin showed no significant difference（P 0.05）,after treatment the index of the two groups were improved（observation group：t = 2.378,t =2.165,t=2.367,t =2.045.Control group：t =2.175,t =2.147,t =2.059,t =2.372,P 0.05）,and the observation group were improved better than the control group（t=2.608,t=2.514,t=2.414,t=2.389,P0.05）.Before treatment,two groups of gastric cancer marker AKP,CEA and CA199 levels＇ difference were not statistically significant（P0.05）.After treatment the index of the two groups were improved（observation group：t=2.174,t=2.279,t=2.141.Control group：t=2.154,t=2.049,t=2.387,P0.05）,and the observation group improved significantly better than the control group（t=2.412,t=2.389,t=2.369,P0.05）.After usage of the drug,patients＇ major adverse reactions including cell reduce,diarrhea,oral mucositis and neurotoxicity etc.,but the adverse reactions of the two groups of patients occurred rate differences were not statistically significant（χ~2=0.740,X^2=0.390,χ~2=0.510,X^2=0.420,P0.05）.Conclusion Thymalfasin injection combined with chemotherapy for gastric carcinoma in elderly patients with liver metastasis patients were found to be more effective,improve the quality of life of patients and improve liver function and does not increase the adverse drug reactions,it is worth of clinical application.
出处
《疑难病杂志》
CAS
2016年第7期694-697,共4页
Chinese Journal of Difficult and Complicated Cases
基金
陕西省自然科学基金资助项目(2013JC2-14)
西安市卫生局科研基金项目(2013-07)
关键词
胸腺法新注射液
胃癌
肝转移
化疗
Thymosinal injection
Gastric cancer
Liver metastasis
Chemotherapy
