摘要
目的探究听觉统合训练(auditory integration training,AIT)对存在脑干听觉传导通路功能障碍的孤独症谱系障碍(autism spectrum disorders,ASD)患儿的疗效。方法56例脑干听觉诱发电位(brainstem auditory evoked potential,BAEP)异常的ASD患儿(年龄2~6岁)接受AIT,每疗程结束后复查BAEP,直至检测结果恢复正常或不再有明显变化。分别在治疗前后对患儿进行孤独症行为评定量表(ABC)及儿童孤独症评定量表(CARS)评估。结果56例患儿平均接受AIT(1.95±0.92)个疗程。与治疗前比较,治疗后56例患儿的CARS评分下降[(36.32±3.54)分,(34.11±3.12)分],差异有统计学意义(P〈0.05);ABC的感觉因子分[(5.65±4.61)分,(4.28±4.11)分]及躯体运动因子分[(8.38±6.12)分,(5.43±5.40)分]下降,差异有统计学意义(P〈0.05)。训练后56例患儿BAEP复查正常29例(51.79%),与治疗前比较,治疗后BAEP左侧Ⅰ波潜伏期[(1.81±0.17)ms,(1.71±0.12)ms]、Ⅲ波潜伏期[(4.14±0.18)ms,(4.07±0.17)ms]、Ⅴ波潜伏期[(6.09±0.23)ms,(5.97±0.22)ms]及右侧Ⅰ波潜伏期[(1.79±0.17)ms,(1.74±0.13)ms]、Ⅲ波潜伏期[(4.15±0.16)ms,(4.07±0.16)ms]、Ⅴ波潜伏期[(6.06±0.23)ms,(5.99±0.26)ms]缩短,差异有统计学意义(P〈0.05)。结论AIT可以改善ASD患儿的脑干听觉传导通路功能障碍,同时能改善ASD症状。
Objective To investigate the curative effect of auditory integration training (AIT) on autism spectrum disorders (ASD) in children with abnormal brainstem auditory evoked potential (BAEP). Methods 56 cases of ASD patients with abnormal BAEP were treated with AIT ( aged 2-6 years). BAEP will be reviewed after each course of treatments until the test results were back to normal or had no obvious changes. Children' s core symptoms were evaluated by using autism behavior checklist (ABC) and the childhood autism rating scale (CARS) before and after treatments. Results 56 children accepted (1.95±0.92) courses of AIT. Compared with the data before AIT,CARS scores ( (36.32±3.54), (34.11±3.12)) ,scores of the sensory factor( ( 5.65±4.61 ), (4.28±4.11 ) ) and the stereotypes factor of ABC were decreased significantly(P〈0.05). After treatments, BAEP of 29 cases (51.79%) went back to normal levels. The bilateral wave incubation periods on left side ( Ⅰ : ( 1.81 ±0.17 ) ms, ( 1.71 ± 0.12 ) ms, Ⅲ : ( 4.14±0. 18 ) ms, ( 4.07±0.17)ms,V: (6.09±0.23) ms, (5.97±0.22) ms ) and right side (Ⅰ: (1.79±0.17) ms, (1.74±0.13) ms,Ⅲ: (4.15 +0.16) ms, ( 4.07 ±0.16) ms, Ⅴ : ( 6.06 ±0.23 ) ms, ( 5.99±0.26) ms) were significantly shortened (P〈 0.05). Conclusion AIT can improve the functional handicap of auditory pathway in brainstem of ASD children,and the core symptoms of ASD.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2016年第7期615-619,共5页
Chinese Journal of Behavioral Medicine and Brain Science
基金
南京市医学科技发展资金资助项目(ZKX14043)
关键词
听觉统合训练
脑干听觉诱发电位
孤独症谱系障碍
核心症状
疗效
Auditory integration training
Brain stem auditory evoked potential
Autism spectrum disorders
Core symptoms
Effects