摘要
目的探讨人类冻融胚胎质量与临床妊娠结局的关系。方法回顾性分析了738例进行玻璃化冷冻的人类冻融胚胎移植（FET）患者的相关资料,根据移植优质胚胎的数量、卵裂球损伤的程度、移植胚胎中是否含8细胞胚胎以及含8细胞胚胎的数目,将其分为4组,分别比较各组间的临床妊娠率和多胎率之间的差异。结果 ①移植2枚优质胚胎组临床妊娠率均高于移植0枚优质胚胎组和移植1枚优质胚胎组（P〈0.05）,并且与移植3枚优质胚胎组基本相同;各组间的多胎率差异无统计学意义;②移植胚胎完整组、损伤组、损伤混合组各组间的临床妊娠率、多胎率差异均无统计学意义;③移植8细胞胚胎组的临床妊娠率显著高于移植6-7或9-13细胞胚胎组（P〈0.05）,且多胎率差异无统计学意义。④移植2枚8细胞胚胎组的种植率、临床妊娠率显著高于移植0枚8细胞胚胎组和移植1枚8细胞胚胎组（P〈0.05）;移植3枚8细胞胚胎组的多胎率显著高于移植0枚8细胞胚胎组（P〈0.05）,其余组间差异无统计学意义。结论 FET中移植的优质胚胎数目和8细胞胚胎数目是影响临床妊娠率和多胎率的重要因素;胚胎损伤对临床妊娠率和多胎率无明显影响。因此,FET时移植至少1枚优质胚胎或1枚8细胞胚胎,既可以保证其临床妊娠率,同时又可以降低多胎率。
Objective To investigate the relationship between the quality of human post-thawed embryo and clinical outcome of pregnancy. Methods A retrospective analysis was performed of data from 738 patients who received frozen-thawed embryos transfer（FET） after vitrification. According to the number of high-quality embryos, the severity of blastomeredamage, whether or not the transplanted embryos contain 8-embryonic cells, and the number of8-embryonic cells, the patients were divided into four groups. The clinical pregnancy rate and the multiple pregnancy rate were compared between the groups. Results （1）The clinical pregnancy rate in patients transferred with two highquality embryos was higher than in patients with one or no high-quality embryo（P〈0.05）, and was comparable to those with three high-quality embryos; however, the multiple pregnancy rate did not differ among groups. （2）There were no statistical differences in clinical pregnancy rate and multiple pregnancy rate among patients transferred with intact,completely damaged or partially damaged embryos.（ 3）The clinical pregnancy rate in patients transferred with 8-cell embryos was higher than in those with 6-7 or 9-13 cell embryos（P〈0.05）; however, the multiple pregnancy rate did not differ among groups. （4）The clinical pregnancy rate in patients transferred with two 8-cell embryos was higher than in those with one or no 8-cell embryos（P〈0.05）; the multiple pregnancy rate in patients transferred with three 8-cell embryos was significantly higher than in those with no 8-cell embryos（P〈0.05）. There was no statistical difference among other groups. Conclusion In FET, the number of high-quality embryos and the number of 8-cell embryos are important factorsfor clinical pregnancy rate and multiple pregnancy rate. Embryo injury does not affect the clinical pregnancy rate and multiple pregnancy rate. Therefore, transferring at least one high-quality embryo or only one 8-cell embryo in FET may ensure that the clinical pregnancy rate and meanwhile reduce the multiple pregnancy rate.
出处
《中国药物与临床》
CAS
2016年第7期951-954,共4页
Chinese Remedies & Clinics
基金
山西省科技攻关项目(20120313025-9)
关键词
胚胎移植
妊娠结局
胚胎质量
Embryo transfer
Pregnancy outcome
Quality of transferred embryo
