摘要
目的研究肿瘤标志物及生化指标联合检测在良、恶性胸腹腔积液诊断中的应用价值。方法选取我院收治的良、恶性胸腔积液患者100例作为研究对象(各50例),检测胸腔积液的癌胚抗原、糖链抗原125及199等肿瘤标志物及总蛋白、乳酸脱氢酶等生化指标,统计分析两组之间各指标是否具有显著差异,同时观察联合检测的准确率、敏感性和特异性。结果研究发现良性胸腹腔积液患者的癌胚抗原、糖链抗原125及199、总蛋白、乳酸脱氢酶等水平均显著低于恶性胸腹腔积液的患者,均有统计学意义(P<0.05)。肿瘤标志物和生化指标检验联合检测的准确性为87.0%,敏感性为92.0%,特异性为80.0%,显著优于单独检测时的结果。结论癌胚抗原、糖链抗原125及199肿瘤标志物及总蛋白、乳酸脱氢酶等生化指标在良、恶性胸腔积液的鉴别诊断中发挥着重要的价值,联合检测各项指标,可有效提高诊断的准确度和灵敏度,值得临床推广应用。
Objective To study and explore the application value of the detection of tumor markers combined with biochemical indicators in diagnosis of benign and malignant pleural and peritoneal effusions. Methods 100 patients with benign and malignant pleural effusions treated in my hospital were selected as the research objects, 50 cases in each patients, the tumor markers of carcinoembryonic antigen and carbohydrate antigen 125 and 199 etc, and the biochemical indicators of total protein and lactate dehydrogenase in pleural effusion were detected, the indexes of the two groups were to analyze statistically whether these indexes had significant differences, and also to observe the accuracy, sensitivity and specificity of the joint detection. Results The research showed that the carcinoembryonic antigen, carbohydrate antigen 125 and 199, total protein, and lactate dehydrogenase levels etc in patients with benign pleural effusion were significantly lower than those in patients with malignant pleural and peritoneal effusions, the comparison had statistical significance（P〈0.05）. For the detection of tumor markers combined with biochemical indicators, the accuracy was 87.0%, the sensitivity was 92.0% and the specificity was 80.0%, which were significantly better than the results of the single detection. Conclusion The tumor markers of carcinoembryonic antigen and carbohydrate antigen 125 and 199, and the biochemical indicators of total protein and lactate dehydrogenase etc in differential diagnosis of benign and malignant pleural effusion played an important value, the combined detection indicators could effectively improve diagnostic accuracy and sensitivity, which was worthy of clinical promotion and application.
出处
《中国医药科学》
2016年第11期147-149,共3页
China Medicine And Pharmacy
关键词
胸腹腔积液
癌胚抗原
糖链抗原125及199
总蛋白
乳酸脱氢酶
Pleural and peritoneal effusion
Carcinoembryonic antigen
Carbohydrate antigen 125 and 199
Total protein
Lactate dehydrogenase
