摘要
目的通过检测妊娠期糖尿病(GDM)患者与正常孕妇血清Chemerin水平变化以及其与血糖、血脂、BMI等指标的相关性,从而探讨血清Chemerin和GDM的关系。方法根据IADPSG标准选择60例GDM患者,同时选择60例糖量正常孕妇作为正常对照组。分别同时测定分娩前两组的血清Chemerin、空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、空腹胰岛素(FINS)、甘油三酯(TG)及总胆固醇(TC),计算出胰岛素抵抗指数(HOMA-IR)。结果GDM组BMI、TG、FPG、FINS、HOMA-IR、HbA1c及Chemerin均较正常对照组显著升高(P均<0.05)。正常对照组血清Chemerin与FPG、HOMA-IR及TG均成负相关(r分别为-0.45,-0.41,-0.54,P均<0.05),而Chemerin在GDM组与以上指标无相关性,但Chemerin与孕期体质量增加量以及分娩前BMI均具有正相关性(r分别为0.58、0.55,P均<0.05)。结论 GDM患者血清Chemerin水平显著升高,且与孕期体质量增加、分娩前BMI是正相关性,Chemerin可能是参与GDM的发病原因之一。
Objective To explore the relationship of serum Chemerin and GDM by detectting serum Chemerin level,blood glucose,blood lipid and body mass index（ BMI） index between pregnancy gestational diabetes mellitus（ GDM） and normal control group of pregnant women.Methods 60 cases of GDM were selected by IADPSG standard,and 60 normal pregnant women were selected as control group.The serum Chemerin,fasting plasma glucose（ FPG）,glycosylated hemoglobin（ HbA1c）,fasting insulin（ fins）,triglyceride（ TG） and total cholesterol（ TC）in the two groups were detected before and after the birth.And the insulin resistance index（ HOMA-IR） was calculated.Results The BMI,TG,FPG,FINS,HOMA-IR,HbA1 c and Chemerin in the GDM group were significantly higher than those in the normal control group（ P〈0.05）.In the control group,the serum Chemerin,FPG,HOMA-IRand TG showed a negative correlation（ r=-0.45,-0.41,-0.54,P〈0.05） and Chemerin in GDM group and the indexes had no correlation,but Chemerin and maternal body mass and BMI before delivery had positive correlation（ r= 0.58,0.55,P〈 0.05）.Conclusion The level of serum Chemerin in GDM group significantly increased,and it had positive correlation with the increase of maternal body mass and BMI before delivery.Chemerin may be one of the causes of GDM.
出处
《湖北民族学院学报（医学版）》
2016年第2期43-45,共3页
Journal of Hubei Minzu University(Medical Edition)
