摘要
目的 探讨双歧杆菌联合康复新液治疗重度溃疡性结肠炎的疗效观察。方法 选取2012年12月-2015年12月本院收治的150例重度溃疡性结肠炎患者作为研究对象,随机分A组、B组和C组,各50例。在激素治疗的基础上,A组给予双歧杆菌四联活菌片治疗,B组给予康复新液治疗,C组给予双歧杆菌四联活菌片联合康复新液治疗。比较三组的治疗效果,腹泻、便血症状消失时间以及ESR、CRP降至正常时间,结肠镜下表现及不良反应发生情况。结果 C组的总有效率显著高于A组和B组,差异有统计学意义（P〈0.05）。C组的结肠镜下黏膜病总缓解率显著高于A组和B组,差异有统计学意义（P〈0.05）。C组的腹泻、便血症状消失时间以及ESR、CRP降至正常所需时间显著短于A组和B组,差异有统计学意义（P〈0.05）。结论 在激素治疗的基础上联合康复新液和双歧杆菌治疗重度溃疡性结肠炎能更快地改善临床症状,促进黏膜修复,且不良反应少,值得临床推广应用。
Objective To explore the effect of Bifidobacterium combined with Kangfuxin liquid in the treatment of severe ulcerative colitis.Methods 150 severe ulcerative colitis patients from December 2012 to December 2015 in our hospital were selected and randomly divided into group A,group B and group C,50 cases in each group.On the basis of hormone therapy,group A was treated with Bifidobacterium tetravaceine tablets,group B was treated with Kangfuxin liq- uid,group C was treated with Bifidobacterium tetravaccine tablets and Kangfuxin liquid.Therapeutic effect,the symptom disappeared time of diarrhea and hematochezia,the normal time of ESR and CRP recovery,anifestation of colonoscopyand the condition of adverse reaction among the three groups was compared.Results The total effective rate in group C was higher than that in group A and group B,with significant difference （P〈0.05）.The total remission rate of mueosal lesion under eolonoseopy in group C was higher than that in group A and group B,with significant difference （P〈0.05）. The symptom disappeared time of diarrhea and hematoehezia,the normal time of ESR and CRP reeove,3, the normal time of ESR and CRP recovery in group C was shorter than that in group A and group B,with significant difference （P〈 0.05）.Conclusion On the basis of using hormone,combined with Bifidobacterium and Kangfuxin liquid in the treatment severe ulcerative colitis can improve clinical symptoms,promote mucosal repair,with less adverse effects and is worth to popularize apply in clinical.
出处
《中国当代医药》
2016年第20期138-140,共3页
China Modern Medicine
关键词
康复新液
双歧杆菌
溃疡性结肠炎
疗效观察
Kangfuxin liquid
Bifidobacterium
Ulcerative colitis
Effect observation
