摘要
分析《中华人民共和国卫生部药品标准·中药成方制剂》(以下简称《中药成方制剂》)含山楂方剂组方规律,为临床应用及新药研发提供参考。基于中医传承辅助平台(V2.5)软件,对《中药成方制剂》中含山楂方剂收集整理,并构建数据库,采用关联规则、频次统计等数据挖掘方法,对疾病证候、常用药物配伍及组方规律进行分析。含山楂方剂共308首,涉及中药499种,常用药物组合34个,主治疾病18种,选取其中高频药对"山楂-陈皮"、"山楂-茯苓"及2种高频疾病"积滞"、"腹泻"进行药物组合分析,显示山楂不同药对中作用方向大致相同,在不同疾病中治疗作用各异。《中药成方制剂》中含山楂方剂多具有消食导滞之功效,临床应用较为广泛,常与理气健脾药同用,以达到不同的治疗效果;组方规律反应出山楂在治疗不同疾病时的组方特点,为山楂临床科学化应用及健康产品开发提供依据。
To analyze the prescription rules of preparations containing Crataegi Fructus in the drug standards of the People＇s Repub- lic of China Ministry of Public Heahh-Chinese Patent Drug （ hereinafter referred to as Chinese patent drug）, and provide some refer- ences for clinical application and the research and development of new medicines. Based on TCMISS（ V2. 5 ）, the prescriptions contai- ning Crataegi Fruetus in Chinese patent drug were collected to build the database ; association rules, frequency statistics and other data mining methods were used to analyze the disease syndrome, common drug compatibility and prescription rules. There were a total of 308 prescriptions containing Crataegi Fructus, involving 499 kinds of Chinese medicines, 34 commonly used drug combinations, and mainly for 18 kinds of diseases. Drug combination analysis was done with ＂Crataegi Fructus-Citri Reticulatae Pericarpium＂ and ＂Cra- taegi Fructus-Poria＂ as the high-frequency herb pairs and with ＂stagnation＂ and ＂diarrhea＂ as the high-frequency diseases. The results indicated that the Crataegi Fructus in different herb pairs had a roughly same function, and its therapy effect was different in different diseases. The prescriptions containing Crataegi Fructus in Chinese patent drug had the effect of digestion, and they were widely used in clinical application, often used together with spleen-strengthening medicines to achieve different treatment effects ; the prescription rules reflected the prescription characteristics of Crataegi Fructus for different diseases, providing a basis for its clinically scientific application and the research and development of new medicines.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2016年第15期2932-2937,共6页
China Journal of Chinese Materia Medica
基金
国家"重大新药创制"科技重大专项(2014ZX09201021-009)
国家重点基础研究发展计划(973)项目(2015CB554406)
