摘要
细胞周期蛋白(cyclins)是一类通过cyclins激酶(cyclin dependent kinase,CDK)调控细胞周期进而控制细胞增殖的蛋白家族,分为细胞周期正性调节蛋白和负性调节蛋白,其异常表达与胃癌发生发展密切相关。通过一些细胞信号通路调节cyclins进而干预肿瘤的进展是目前胃癌研究的热点。本文就胃癌临床病理特点与cyclins的关系及与cyclins相关的治疗靶点作一综述。
Cyclins are a family of proteins that control the progression of cells through the cell cycle by activating cyclin dependent kinase（CDK）.Cyclins include positive regulatory ones and negative regulatory ones.Abnormal expression of cyclins is closely related with the pathogenesis and progression of gastric cancer.It is the focus of study related with gastric cancer that some cell signal pathways regulate cyclins and impact the progression of the tumor.The present paper reviews the relationship between clinicopathologic characteristics of gastric cancer and cyclins status and the therapeutic target related with cyclins in gastric cancer.
出处
《中国临床医学》
2016年第3期368-373,共6页
Chinese Journal of Clinical Medicine
基金
国家自然基金青年科学基金(81402433)
中国博士后科学基金(2015T81088)~~
