摘要
目的探讨喹硫平联合舍曲林治疗慢性精神分裂症患者的临床效果。方法选取2013年7月至2014年7月商丘市第二人民医院收治的76例慢性精神分裂症患者作为研究对象,根据随机数字表法将其分为观察组和对照组,各38例。对照组患者给予富马酸喹硫平片,观察组患者在对照组基础上采用盐酸舍曲林片,比较两组患者的临床疗效、治疗前后临床症状改善情况及不良反应发生情况。结果观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗6周、12周后,观察组患者的阳性和阴性症状量表(PANSS)评分均显著低于对照组,差异均有统计学意义(均P<0.05)。结论喹硫平联合舍曲林治疗慢性精神分裂症患者临床疗效明显,可有效缓解临床症状,且不良反应少,安全可靠。
Objective To investigate the clinical effect of quetiapine combined with sertraline in the treatment of patients with chronic schizophrenia.Methods From July 2013 to July 2014,76 cases of chronic schizophrenia patients were selected as study subjects.According to the random number table method,it was divided into observation group and control group,each of 38 cases.In control group were treated with quetiapine fumarate sulfur plain film and clinical observation of patients in the control group based on the use of sertraline hydrochloride tablets and compared between the two groups of patients,before and after the treatment,the clinical symptom improvement and adverse reaction incidence.Results Observation of the patients in the treatment group total efficiency was significantly higher than that of the control group,the difference is statistically significant（P〈0.05）;in the treatment of 6 weeks,12 weeks after observed group of patients with positive and negative symptom table（PANSS） scores were significantly lower than those in the control group,differences were statistically significant（P〈0.05）.Conclusion Quetiapine combined with sertraline in the treatment of chronic mental split the clinical curative effect,can effectively alleviate the clinical symptoms,and less adverse reaction, safe and reliable.
出处
《中国药物经济学》
2016年第7期75-76,共2页
China Journal of Pharmaceutical Economics
