摘要
目的探讨间苯三酚联合地西泮用于分娩对产程及母婴结局的影响。方法选择2014年6月至2015年6月收治的足月初产妇92例,随机分为联用组和单用组,各46例。联用组产妇于潜伏期给予间苯三酚80 mg+地西泮10 mg静脉注射,单用组产妇在潜伏期仅给予间苯三酚80 mg静脉注射。观察并记录宫颈成熟情况、产程时间、宫颈变化、妊娠结局及新生儿出生情况。结果联用组产妇宫颈成熟率为86.96%,显著高于单用组的67.39%(P<0.05);联用组产妇产程活跃期较单用组短(P<0.05),第2产程持续时间及用药2 h后宫颈水肿消失率比较,两组无明显差异(P>0.05),用药2 h后,联用组产妇宫口进展较单用组产妇快(P<0.05);联用组剖宫产率明显低于单用组(P<0.05),两组产妇产后出血率、胎儿宫内窘迫发生率及新生儿窒息率比较,差异无统计学意义(P>0.05);两组新生儿阿普加(Apgar)评分(1,5 min)及神经行为与适应能力(NACS)评分(15 min,24 h)均无明显差异(P>0.05);两组产妇用药前后血压、心率均平稳,且无明显不良反应发生。结论间苯三酚联合地西泮用于分娩可改善宫颈条件,加速产程进展,对母体和新生儿有较好的安全性,值得临床推广。
Objective To investigate the effect of phloroglucinol and diazepam on the delivery of labor and maternal- child outcome. Methods 92 cases of full- term primipara from June 2014 to June 2015 were randomly divided into the combined group and the single group,46 cases in each group. The combined group was given benzene phenol 80 mg ＋ diazepam 10 mg intravenous injection in latency; the single group was only given benzene phenol 80 mg intravenous injection in latency. The cervical ripening conditions,time of birth process,the change of cervical,pregnancy outcome and neonatal conditions were observed and recorded. Results The cervical maturing rate of the combined group was 86. 96%,which was significantly higher than 67. 39% of the single group（ P〈0. 05）; the active phase of labor in the combined group was shorter than the single group（ P〈0. 05）; the combined group and single group had no significant difference in the second stage of labor and the cervical edema disappearance rate after 2 h of medication（ P〈0. 05）;after 2 h of medication,the combined group had faster progress than the single group（ P〈0. 05）; the cesarean section rate of the combined group was obviously lower than the single group（ P〈0. 05）; the two groups had no statistically significant different in the postpartum hemorrhage rate,fetal distress and neonatal asphyxia rate（ P〉0. 05）; the Apgar score（ 1,5 min） and NACS（ 15 min,24 h）in the two groups had no significantly difference（ P〉0. 05）. The blood pressure and heart rate were stable and no significant adverse reactions occurred in the 2 groups. Conclusion Phloroglucinol combined with diazepam can improve the cervix for labor conditions to accelerate the progress of labor,enables the mother and the newborn to have better safety,which is worthy of clinical promotion.
出处
《中国药业》
CAS
2016年第14期71-73,共3页
China Pharmaceuticals
关键词
间苯三酚
地西泮
分娩
产程
母婴结局
phloroglucinol
diazepam
deliver
labor
maternal-child outcome
