摘要
目的评价口服避孕药与中国女性乳腺癌的关联性。方法计算机检索中国知网、万方、维普、中国生物医学文献、Pub Med等数据库,结合手工追溯,纳入有关口服避孕药对乳腺癌发病关系的研究。按照拟定的纳入和排除文献标准,提取有效数据,采用Rev Man5.0软件进行Meta分析。结果共纳入28篇病例对照研究,包括8 677例乳腺癌患者和12 150例对照。Meta分析结果显示口服避孕药为乳腺癌发病的危险因素,随机效应模型得到比值比=1.46,95%可信区间1.15~1.87,固定效应模型得到比值比=1.26,95%可信区间1.16~1.38。结论口服避孕药可能会增加中国女性乳腺癌的发病风险。
Objective To evaluate the relevance of oral contraceptives and breast cancer in Chinese women. Methods A comprehensive literature search was performed to find eligible studies for this meta- analysis. Two investigators （Shi, Xu） searched in the PubMed, CBM （Chinese biomedical database）, CNKI （Chinese national knowledge infrastructure） , VIP （Chinese） database and Wanfang （Chinese） Database to identify relevant studies published up to March 2015. The reference lists of the relevant articles were also reviewed. Review Manager 5 （RevMan） software was used for meta analysis. Odd ratio （OR） with 95% confidence intervals （CI） were used to assess the association between oral contraceptive use and risk of breast cancer using random effect models or fixed effect models. Results Finally, 28 case-control studies with 8 677 cases and 12 150 controls were included. The result of meta analysis shows that breast cancer cases have higher exposure of oral contraceptives than control group. （random effect model： OR=1.46, 95% CI 1.15-1.87; fixed effect model： OR=1.26,95%CI 1.16-1.38）. Conclusion Oral contraceptives may increase the risk of breast cancer in Chinese women.
出处
《循证医学》
CSCD
2016年第3期174-179,185,共7页
The Journal of Evidence-Based Medicine
基金
安徽医科大学七年制临床医学专业学生"早期接触科研"训练计划资助项目(2014-ZQKY-66)
