摘要
目的分析结直肠神经内分泌肿瘤患者区域淋巴结的转移特征以及影响淋巴结转移的相关因素。方法 回顾性分析99例结直肠神经内分泌肿瘤患者的临床资料，对其区域淋巴结转移特征及相关影响因素进行统计学分析。结果 本组共30例（30.3%）患者发生区域淋巴结转移，其中17例（56.7%）为肠旁淋巴结转移，8例（26.7%）为肠系膜淋巴结转移，5例（16.7%）为肠系膜根部中央组淋巴结转移，无一例发生跳跃式转移及肠系膜根部远处淋巴结转移。多因素分析结果提示，肿瘤直径、WHO病理分级、淋巴管浸润是独立影响区域淋巴结转移的相关因素（均P〈0.05）。结论 结直肠神经内分泌肿瘤如肿瘤直径较大、病理分级G2、G3级且有淋巴管浸润者其区域淋巴结的转移率则会很高；行根治性切除术中需格外注意肠旁淋巴结以及肠系膜淋巴结的彻底清扫。
Objective To investigate the features and risk factors associated with lymph node metastasis in coloreetal neuroendocrine neoplasm. Methods Clinical and pathological data of 99 patients with colorectal neuroendocrine neoplasm treated between January 2009 to January 2015 were analyzed retrospectively. Comparisons of categorical data and univariate analysis of risk factors of lymph node metastasis were conducted. Results Of the 99 patients, the rate of regional lymph node metastasis was 30. 3% （30/99） with 56. 7% limited to para-intestinal lymph nodes in 17 cases ,26. 7% limited to mesenteric lymph nodes in 8 cases,and 16. 7% limited to mesenteric root central lymph nodes in 5 cases. No metastasis exceeding cen- tral lymph nodes was observed. Multivariate regression analysis revealed that tumor size, invasion of lymphatic vessel and pathological grading were independent risk factors for lymph node metastasis in eolorectal neuroendocrine neoplasm （ P 〈 0. 05 ）. Conclusions Colorectal neuroendoerine neoplasm with larger tumor size, invasion of lymphatic vessel or higher grade （ G2, G3 ） has high risk of regional lymph node metastasis.
出处
《中国医师杂志》
CAS
2016年第7期1031-1034,共4页
Journal of Chinese Physician
关键词
结直肠肿瘤
癌
神经内分泌
淋巴转移
Colorectal neoplasms
Carcinoma, neuroendocrine
Lymphatic metastasis
