摘要
目的分析盐酸米诺环素治疗牙周牙髓综合征的临床疗效及安全性。方法将2013年9月至2015年8月之间来我院进行治疗的108例牙周牙髓综合征患者作为观察对象,随机分为实验组52例及对照组56例。两组患者采取相同的基础治疗措施,对照组患者的牙周袋中注入盐酸米诺环素软膏进行处理;实验组则通过根管途径注入适量的盐酸米诺环素软膏进行治疗,待达到根管充填标准之后进行充填。对比两组患者治疗前后的菌斑指数、牙周袋探诊深度、牙龈指数等指标结果,同时评价两组的治疗有效率。结果实验组患者治疗后的菌斑指数、牙周袋探诊深度、牙龈指数显著优于对照组,差异具有统计学意义(P<0.05);同时,对比两组的治疗有效率差异结果同样具有统计学意义(P<0.05);实验组和对照组患者的不良反应均较轻,组间对比,差异无统计学意义(P>0.05)。结论在常规治疗的基础上应用根管途径注入盐酸米诺环素治疗牙周牙髓综合征的临床效果较好,且不会增加不良反应发生率,具有较高的治疗效果及安全性,值得在临床中推广。
Objective To analyze the clinical efficacy and safety of minocycline hydroehloride in the treatment of periodontal pulp syndrome. Methods 108 cases of patients suffering from periodontal pulp syndrome, got treatment in our hospital during September 2013 and August 2015, were selected as research objects, and they were divided into observation group （ n = 52 ） and control group （ n = 56 ） according to the patient＇s medical record number. Two groups of patients taken the same basic treatment, the patients in the control group were injected minocycline hydrochloride in periodontal pocket for processing. The patients in observation group were given minocycline hydrochloride ointment through the canal route for treatment. When reached roots filling standard, the canal were filled. Plaque index probing pocket depth indicator results and gingival index of the two groups of patients （both before and after the treatment） were compared, meanwhile the effectiveness of the two groups were evaluated. Results The plaque index, periodontal pocket probing depth and gingival index observed in patients after treatment were significantly better than the reference group, the difference was statistically significant （ P 〈 0. 05 ）. The difference of treatment efficiency of the two groups was statistically significant （ P 〈 0. 05 ）. Bothe the observation group and reference group with mild adverse reactions, the difference was not statistically significant （P 〉 0. 05 ）. Conclusions On the basis of conventional therapy the application of minocycline hydrochloride for the treatment of periodontal pulp syndrome was effective, and does not increase the incidence of adverse reactions, has a high therapeutic efficacy and safety, it is worth of clinical promotion.
出处
《齐齐哈尔医学院学报》
2016年第13期1690-1692,共3页
Journal of Qiqihar Medical University
关键词
盐酸米诺环素
牙周牙髓综合征
临床疗效
安全性
Minocycline hydrochloride
Periodontal pulp syndrome
Clinical efficacy
Safety
