摘要
[目的]探讨缺氧诱导因子-1α(HIF-1α)、骨桥蛋白(OPN)及c-Met在胆管癌组织中的表达及其临床意义。[方法]采用免疫组化SP法检测HIF-1α、OPN及c-Met在56例胆管癌、30例癌旁正常胆管组织中的表达情况,并分析其与临床病理特征关系及三者的相关性。[结果 ]HIF-1α、OPN及c-Met在胆管癌组织中的表达均明显高于癌旁正常胆管组织,并且在胆管癌组织中表达与患者年龄、性别、肿瘤大小、肿瘤部位、分化程度无相关性(P>0.05),而与肿瘤分期、有无淋巴结转移有关(P<0.05)。HIF-1α、OPN及c-Met在胆管癌组织样本中表达均呈正相关(P<0.05)。[结论]HIF-1α、OPN及c-Met在胆管癌组织中高表达,与肿瘤侵袭转移关系密切。
[Objective] To explore the expressions of HIF-1α,OPN and c-Met in cholangiocarcinoma and their significance.[Methods] The expression of HIF-1α,OPN and c-Met in cholangiocarcinoma issue samples of 56 cases and bile duct tissue samples adjacent to carcinoma of 30 cases were detected by immunohistochemical SP methods.The relationship with clinical pathological features and their correlation were analyzed.[Results ] The expression of HIF-1α,OPN and c-Met in cholangiocarcinoma were significantly higher than those in bile duct tissue adjacent to carcinoma.The strong positive expression in cholangiocarcinoma wasn ＇t related with age,sex,tumor size,tumor location and differentiation degree,while was related with tumor stage and lymph node metastasis（P〈0.05）.There were positive correlations between HIF-1α,OPN and c-Met expression in cholangiocarcinoma（P〈0.05）.[Conclusion] The expressions of HIF-1α,OPN and c-Met are higher in cholangiocarcinoma,and are closely associated with tumor invasion and metastasis.
出处
《肿瘤学杂志》
CAS
2016年第8期643-647,共5页
Journal of Chinese Oncology
