摘要
目的:优化参芪益气胶囊的水提工艺。方法:以黄芪甲苷、毛蕊异黄酮葡萄糖苷、淫羊藿苷和岩白菜素提取率等为指标进行综合评分,以加水倍数、煎煮次数、煎煮时间为考察因素,采用L9(34)正交试验优化参芪益气胶囊中药材的水提工艺并进行验证试验。结果:最优提取工艺为加8倍量水煎煮3次,每次2 h;验证试验中3批样品提取后的综合评分分别为98.95、99.71、99.98(RSD<2%,n=3)。结论:采用多指标综合评分-正交试验法优化的参芪益气胶囊的水提工艺稳定、科学、合理。
OBJECTIVE：To optimize water extraction technology of Shenqi yiqi capsules. METHODS：The water extraction technology of Shenqi yiqi capsules was optimized by L9（34）orthogonal test with amount of water added,decoction times and decoction time as factors using the extraction rate of astragaloside,calyosin-7-O-β-D-glycoside,icariin and bergenin as index,and the verification test was made. RESULTS：The best extraction technology was as follows as 8-fold water,decocting for 3 times,2 h each time;comprehensive score of 3 batches of samples in validation test were 98.95,99.71 and 99.98（RSD〈2%,n=3）. CONCLUSIONS：The water extraction technology optimized by multi-index comprehensive score-orthogonal test is stable,scientific and reasonable.
出处
《中国药房》
CAS
北大核心
2016年第22期3139-3141,共3页
China Pharmacy
关键词
参芪益气胶囊
提取工艺
正交试验
多指标综合评分
Shenqi yiqi capsules
Extraction technology
Orthogonal test
Multi-index comprehensive score
