摘要
目的 :探讨辛伐他汀对维持性血液透析患者的血清细胞高敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)和脂联素(ADPN)水平的影响。方法 :回顾性分析2013年5月—2015年5月我院肾内科收治的维持性血液透析患者80例,按其是否用药分为辛伐他汀组和对照组,辛伐他汀组给予辛伐他汀+血液透析治疗,剂量为20 mg/d,对照组单纯给予血液透析治疗。比较两组患者治疗前、治疗6个月后血清hs-CRP、IL-6和ADPN水平,同时测定治疗前、后患者的血脂TG、TC、LDL、HDL的水平,观察并记录患者治疗期到治疗结束1年内发生的心血管事件。结果 :与对照组比较,辛伐他汀组治疗后血清hs-CRP、IL-6的水平均有所下降,ADPN水平升高,血脂TG、TC、LDL水平下降,HDL水平升高。辛伐他汀组发生的心血管事件有6例,发生率为15%,显著低于对照组发生的心血管事件13例,发生率为32.5%,组间差异有统计学意义(P<0.05)。结论 :辛伐他汀能降低维持性血液透析患者的血清hs-CRP、IL-6水平,并使ADPN水平升高,具有良好的抗炎、降血脂作用,能有效改善维持性血液透析患者动脉粥样硬化症状,降低心血管事件的发生率。
Objective： To discuss the effect of simvastatin on the maintenance of the levels of serum high-sensitivity C-reactive protein（hs-CRP）, interleukin 6（IL-6） and adiponectin（ADPN） in the treatment of hemodialysis patients. Methods：The data from 80 patients with maintenance hemodialysis were retrospectively analyzed and the patients were divided into a simvastatin group and a control group according to whether or not they were taking simvastatin. The simvastatin group received 20 mg of simvastatin daily plus hemodialysis treatment while the control group only hemodialysis. The serum hs-CRP, IL-6 and ADPN levels and the levels of serum TG, TC, LDL and HDL in all patients were simultaneously determined before treatment and 6 months after and then analyzed. The cardiovascular events occurred within 1 year from the end of the treatment were also observed. Results： The levels of serum hs-CRP, IL-6, TG, TC and LDL were reduced while the levels of ADPN and HDL were increased in the simvastatin group after treatment compared with those in the control group. There were 6 cases of cardiovascular events in the simvastatin group and 13 cases in the control group（15% vs 32.5%, P〈0.05）. Conclusion： Simvastatin can reduce the serum hs-CRP and IL-6 levels and increase ADPN level with a good anti-inflammatory and lipid-lowering function and can effectively improve the symptoms of atherosclerosis and reduce the incidence of cardiovascular events for patients with maintenance hemodialysis.
出处
《上海医药》
CAS
2016年第15期22-25,共4页
Shanghai Medical & Pharmaceutical Journal
基金
2015年江西省卫生厅科研计划(普通)课题(项目编号:20154050)
关键词
辛伐他汀
维持性血液透析
脂联素
微炎症
心血管事件
simvastatin
maintenance hemodialysis
adiponectin
microinflammation
cardiovascular event
